Author

C. J. Copeland

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Immunology· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

B. Kim· 1 shared C. M. Backlund· 1 shared D. J. Irvine· 1 shared K. B. Nguyen· 1 shared M. E. Birnbaum· 1 shared N. G. Klop-Packel· 1 shared N. K. Singh· 1 shared S. Spranger· 1 shared

Activity by Year

2022-2022 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

B. Kim

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1 paper

Recent·Most cited

Decoupled neoantigen cross-presentation in tumors with high intratumor heterogeneity reduces dendritic cell activation to limit anti-tumor immunity

K. B. Nguyen, C. J. Copeland, C. M. Backlund, N. G. Klop-Packel, T. Remba, B. Kim, N. K. Singh, M. E. Birnbaum, D. J. Irvine, S. Spranger

This study shows that clonal neoantigen expression enhances dendritic cell activation and anti-tumor immunity, while subclonal expression reduces it in tumors with high intratumor heterogeneity.

bioRxiv · Dec 16, 2022Immunology