ImmunologybioRxiv
Decoupled neoantigen cross-presentation in tumors with high intratumor heterogeneity reduces dendritic cell activation to limit anti-tumor immunity
K. B. Nguyen, C. J. Copeland, C. M. Backlund…·S. Spranger
This study shows that clonal neoantigen expression enhances dendritic cell activation and anti-tumor immunity, while subclonal expression reduces it in tumors with high intratumor heterogeneity.
DOI 10.7554/elife.85263