N. K. Singh

Pharmacology of Berberine and its Metabolites, is it the natures Ozempic or Imatinib?

This study evaluates the pharmacology of berberine and its metabolites using in silico tools, identifying novel high-affinity targets and potential mechanisms of action.

Genomic analysis reveals the presence of emerging pathogenic Klebsiella lineages aboard the International Space Station.

This study analyzes Klebsiella isolates from the International Space Station, revealing emerging pathogenic lineages with resistance genes and potential for horizontal gene transfer.

Decoupled neoantigen cross-presentation in tumors with high intratumor heterogeneity reduces dendritic cell activation to limit anti-tumor immunity

This study shows that clonal neoantigen expression enhances dendritic cell activation and anti-tumor immunity, while subclonal expression reduces it in tumors with high intratumor heterogeneity.

An unbiased characterization of the HLA-E and CD94/NKG2x peptide repertoire reveals peptide ligands that skew NK cell activation

The paper identifies 500 HLA-E-bound peptides that bind CD94/NKG2A or CD94/NKG2C, revealing ligands that modulate NK cell activation.

Genome-wide association mapping reveals genes underlying population-level metabolome diversity in a fungal crop pathogen

The paper maps genetic loci associated with metabolome diversity in Zymoseptoria tritici using metabolite-GWAS, identifying SNPs in coding and regulatory regions linked to metabolite production.

Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma

The paper identifies a dominant tumor-associated antigen in murine melanoma and shows that engineered mimotopes can induce cross-reactive T cell responses.

SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses

This study shows that the SARS-CoV-2 Delta variant suppresses innate immune responses and evades interferon activation more effectively than earlier variants.

Genetic and Immunological Evidence for Microbial Transfer Between the International Space Station and an Astronaut

The paper tracks microbial transfer between an astronaut and the ISS environment, identifies specific taxa, and shows immune system adaptation.

The complex genomic basis of rapid convergent adaptation to pesticides across continents in a fungal plant pathogen

This study identifies genomic factors underlying pesticide resistance in Zymoseptoria tritici across continents, finding both convergent and population-specific genetic changes.

Molecular characterization and differential expression reveal functional divergence of stress-responsive enzymes in C4 panicoid models, Setaria italica and Setaria viridis

The paper identifies and characterizes stress-responsive genes in C4 plants Setaria italica and S. viridis, highlighting key candidates for abiotic stress tolerance.

Draft genome sequence of a popular Indian tea genotype TV-1

The paper presents the first draft genome sequence of the Indian tea cultivar TV-1, providing insights into its genetic structure and potential for distinguishing it from other tea varieties.

Analysis of genetic control and QTL mapping of essential wheat grain quality traits in a recombinant inbred population

The paper analyzes genetic control and maps QTLs for wheat grain quality traits in a recombinant inbred population across three environments, identifying 38 putative QTLs explaining 7.9% to 16.8% phenotypic variation.