Author

C. J. Langouët-Astrie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1

Frequent Co-Authors

A. R. Horswill· 4 shared E. P. Schmidt· 3 shared A. L. Haeberle· 1 shared B. A. Duerkop· 1 shared B. D. McCollister· 1 shared C. L. Erzen· 1 shared C. Robertson· 1 shared D. Frank· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersMicrobiology

A. R. Horswill

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4 papers

Recent·Most cited

MicrobiologybioRxivJul 14, 2023

Rgg2/Rgg3 quorum sensing is a determinant of Streptococcus pyogenes-host interactions in a murine intact skin infection model

R. V. Wilkening, C. J. Langouët-Astrie, M. M. Severn…·A. R. Horswill

This study shows that the Rgg2/Rgg3 quorum sensing system is essential for Streptococcus pyogenes to establish and maintain skin infections in a mouse model.

DOI 10.1016/j.celrep.2023.113332

mousebulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivJan 10, 2023

Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity.

J. F. Colbert, J. M. Kirsch, C. L. Erzen…·E. P. Schmidt

This study shows that aging increases gut microbial virulence, contributing to more severe sepsis in older adults.

DOI 10.1128/mbio.00052-23

mousemetagenomics

𝕏 PostBluesky

MicrobiologybioRxivPreprintDec 13, 2022

Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG

H. Crosby, K. C. Keim, J. Kwiecinski…·A. R. Horswill

This study shows that host-derived protease cleaves SasG, promoting S. aureus aggregation and virulence in mouse infections.

DOI 10.1101/2022.12.13.520364

mouseproteomics

𝕏 PostBluesky

MicrobiologybioRxivJun 27, 2022

Group B Streptococcus Adaptation Promotes Survival in a Hyper-inflammatory Diabetic Wound Environment

R. A. Keogh, A. L. Haeberle, C. J. Langouët-Astrie…·K. S. Doran

This study shows that Group B Streptococcus adapts to the hyper-inflammatory environment of diabetic wounds by upregulating virulence factors, leading to increased survival.

DOI 10.1126/sciadv.add3221

mousebulk RNA-seq

𝕏 PostBluesky