Author

A. R. Horswill

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 13 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 14 Research Focus:host-pathogen & immune response· 13 Organism:mouse· 7 Organism:human· 4 Assay:bulk RNA-seq· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

C. J. Langouët-Astrie· 4 shared E. P. Schmidt· 3 shared H. Crosby· 3 shared J. Kwiecinski· 3 shared K. B. Mills· 3 shared A. B. Herr· 2 shared J. J. Maciag· 2 shared J. S. Kavanaugh· 2 shared

Activity by Year

2019-2024 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersMicrobiology

C. J. Langouët-Astrie

Mutual co-authors in cluster

Author profile →

14 papers

Recent·Most cited

Androgens at the skin surface regulate S. aureus pathogenesis through the activation of agr quorum sensing

M. S. John, M. Chinnappan, M. Artami, M. Bhattacharya, R. Keogh, J. Kavanaugh, T. Sharma, A. R. Horswill, T. A. Harris-Tryon

This study shows that androgens like testosterone promote S. aureus pathogenesis by activating the agr quorum sensing system, leading to increased virulence and skin infection.

bioRxiv · Feb 10, 2024 · PreprintMicrobiology

Staphylococcus aureus skin colonization is mediated by SasG lectin variation

K. B. Mills, J. J. Maciag, C. Wang, J. A. Crawford, T. J. Enroth, K. C. Keim, Y. F. Dufrene, D. A. Robinson, P. D. Fey, A. B. Herr, A. R. Horswill

This study identifies SasG-II, a variant of the S. aureus surface protein, which binds to a broader range of ligands, enhancing its ability to colonize skin.

bioRxiv · Nov 20, 2023 · PreprintMicrobiology

X-ray-driven chemistry and conformational heterogeneity in atomic resolution crystal structures of bacterial dihydrofolate reductases

N. Smith, A. R. Horswill, M. A. Wilson

This study shows X-rays can drive hydride transfer in bacterial DHFRs, revealing conformational changes and catalytic dynamics through high-resolution crystal structures.

bioRxiv · Nov 7, 2023 · PreprintBiochemistry

Micrococcal nuclease regulates biofilm formation and dispersal in methicillin-resistant Staphylococcus aureus USA300

J. B. Kaplan, A. P. Florjanczyk, M. Ochiai, C. D. Jones, A. R. Horswill

This study shows that Nuc1 in MRSA regulates biofilm formation, dispersal, and the size of detached cell aggregates by degrading extracellular DNA.

bioRxiv · Nov 5, 2023 · PreprintMicrobiology

The Staphylococcus aureus regulatory program in a human skin-like environment

A. R. Horswill, F. Costa, K. B. Mills, H. Crosby

This study develops a cost-effective media to mimic the human skin environment and shows it enhances the expression of virulence factors in MRSA.

bioRxiv · Oct 24, 2023 · PreprintMicrobiology

Rgg2/Rgg3 quorum sensing is a determinant of Streptococcus pyogenes-host interactions in a murine intact skin infection model

R. V. Wilkening, C. J. Langouët-Astrie, M. M. Severn, M. J. Federle, A. R. Horswill

This study shows that the Rgg2/Rgg3 quorum sensing system is essential for Streptococcus pyogenes to establish and maintain skin infections in a mouse model.

bioRxiv · Jul 14, 2023Microbiology

Mechanistic basis of staphylococcal interspecies competition for skin colonization

J. J. Maciag, C. Chantraine, K. B. Mills, R. Yadav, A. E. Yarawsky, C. T. Chaton, D. Vinod, N. C. Fitzkee, M. Mathelie-Guinlet, Y. F. Dufrene, P. D. Fey, A. R. Horswill, A. B. Herr

This study investigates the structural and functional basis of staphylococcal adhesion to skin and reveals cross-inhibition between S. epidermidis and S. aureus.

bioRxiv · Jan 26, 2023 · PreprintMicrobiology

Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity.

J. F. Colbert, J. M. Kirsch, C. L. Erzen, C. J. Langouët-Astrie, G. E. Thompson, S. A. McMurtry, J. M. Kofonow, C. Robertson, E. J. Kovacs, R. C. Sullivan, J. A. Hippensteel, N. V. Sawant, N. J. De Nisco, B. D. McCollister, R. S. Schwartz, , E. P. Schmidt

This study shows that aging increases gut microbial virulence, contributing to more severe sepsis in older adults.

bioRxiv · Jan 10, 2023Microbiology

Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG

H. Crosby, K. C. Keim, J. Kwiecinski, C. J. Langouët-Astrie, K. Oshima, W. B. LaRiviere, E. P. Schmidt, A. R. Horswill

This study shows that host-derived protease cleaves SasG, promoting S. aureus aggregation and virulence in mouse infections.

bioRxiv · Dec 13, 2022 · PreprintMicrobiology

Group B Streptococcus Adaptation Promotes Survival in a Hyper-inflammatory Diabetic Wound Environment

R. A. Keogh, A. L. Haeberle, C. J. Langouët-Astrie, J. S. Kavanaugh, E. P. Schmidt, G. D. Moore, A. R. Horswill, K. S. Doran

This study shows that Group B Streptococcus adapts to the hyper-inflammatory environment of diabetic wounds by upregulating virulence factors, leading to increased survival.

bioRxiv · Jun 27, 2022Microbiology

Pyochelin biotransformation by Staphylococcus aureus shapes bacterial competition with Pseudomonas aeruginosa in polymicrobial infections

C. Jenul, K. Keim, J. Jens, M. J. Zeiler, K. Schilcher, M. Schurr, C. Melander, V. V. Phelan, A. R. Horswill

This study shows that Staphylococcus aureus uses pyochelin methylation via Spm to outcompete Pseudomonas aeruginosa in co-infections.

bioRxiv · Apr 18, 2022 · PreprintMicrobiology

Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro biofilm and in vivo implant infections

L. de Vor, B. van Dijk, K. P. van Kessel, J. S. Kavanaugh, C. J. de Haas, P. C. Aerts, M. C. Viveen, E. C. Boel, A. C. Fluit, J. M. Kwiecinski, G. C. Krijger, R. M. Ramakers, F. J. Beekman, E. Dadachova, M. G. Lam, , S. H. Rooijakkers

The paper identifies human monoclonal antibodies that recognize Staphylococcus aureus biofilms in vitro and in vivo, with some specifically targeting biofilm-associated antigens.

bioRxiv · Feb 9, 2021 · PreprintMicrobiology

MgrA regulates interaction of Staphylococcus aureus with mucin

C. P. Parker, N. Akil, C. R. Shanrock, P. D. Allen, A. L. Chaly, H. Crosby, J. Kwiecinski, A. R. Horswill, A. J. Fischer

The paper measures S. aureus binding to mucin and identifies MgrA and Ebh/SraP as regulators of this interaction.

bioRxiv · Apr 9, 2020 · PreprintMicrobiology

Identification of key determinants of Staphylococcus aureus vaginal colonization

L. Deng, K. Schilcher, L. R. Burcham, J. Kwiecinski, P. M. Johnson, S. R. Head, D. E. Heinrichs, A. R. Horswill, K. Doran

This study identifies fibrinogen binding and iron acquisition as key determinants of MRSA vaginal colonization using a mouse model and transcriptomic analysis.

bioRxiv · Sep 10, 2019Microbiology