K. S. Doran

Heterogeneity of the group B streptococcal type VII secretion system and influence on colonization of the female genital tract

This study characterizes the heterogeneity of the T7SS in GBS and shows subtype-specific effects on host colonization and gene expression.

Group B Streptococcus Adaptation Promotes Survival in a Hyper-inflammatory Diabetic Wound Environment

This study shows that Group B Streptococcus adapts to the hyper-inflammatory environment of diabetic wounds by upregulating virulence factors, leading to increased survival.

A type VII secretion system in Group B Streptococcus mediates cytotoxicity and virulence

This study identifies a type VII secretion system in Group B Streptococcus that contributes to virulence and cytotoxicity through the WXG100 effector EsxA.

Identification of a novel cationic glycolipid in Streptococcus agalactiae that contributes to brain entry and meningitis

This study identifies a novel cationic glycolipid in Streptococcus agalactiae that enhances its ability to invade the blood-brain barrier and cause meningitis.

Genome-wide mutagenesis identifies factors involved in Enterococcus faecalis vaginal adherence and persistence

This study identifies bacterial factors important for Enterococcus faecalis vaginal colonization and persistence using a transposon mutagenesis screen in a mouse model.

Bacterial protein domains with a novel Ig-like fold bind human CEACAM receptors

This study identifies a novel Ig-like fold in bacterial adhesins that binds human CEACAM receptors, suggesting a broad mechanism for bacterial pathogenesis.

The Group B Streptococcal surface antigen I/II protein, BspC, interacts with host vimentin to promote adherence to brain endothelium and inflammation during the pathogenesis of meningitis