Author

E. P. Schmidt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

A. R. Horswill· 3 shared C. J. Langouët-Astrie· 3 shared A. Frazer-Abel· 1 shared A. L. Haeberle· 1 shared A. Maljuf-Cruz· 1 shared A. Verma· 1 shared B. A. Duerkop· 1 shared B. D. McCollister· 1 shared

Activity by Year

2022-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

A. R. Horswill

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity.

J. F. Colbert, J. M. Kirsch, C. L. Erzen, C. J. Langouët-Astrie, G. E. Thompson, S. A. McMurtry, J. M. Kofonow, C. Robertson, E. J. Kovacs, R. C. Sullivan, J. A. Hippensteel, N. V. Sawant, N. J. De Nisco, B. D. McCollister, R. S. Schwartz, , E. P. Schmidt

This study shows that aging increases gut microbial virulence, contributing to more severe sepsis in older adults.

bioRxiv · Jan 10, 2023Microbiology

Host-derived protease promotes aggregation of Staphylococcus aureus by cleaving the surface protein SasG

H. Crosby, K. C. Keim, J. Kwiecinski, C. J. Langouët-Astrie, K. Oshima, W. B. LaRiviere, E. P. Schmidt, A. R. Horswill

This study shows that host-derived protease cleaves SasG, promoting S. aureus aggregation and virulence in mouse infections.

bioRxiv · Dec 13, 2022 · PreprintMicrobiology

Group B Streptococcus Adaptation Promotes Survival in a Hyper-inflammatory Diabetic Wound Environment

R. A. Keogh, A. L. Haeberle, C. J. Langouët-Astrie, J. S. Kavanaugh, E. P. Schmidt, G. D. Moore, A. R. Horswill, K. S. Doran

This study shows that Group B Streptococcus adapts to the hyper-inflammatory environment of diabetic wounds by upregulating virulence factors, leading to increased survival.

bioRxiv · Jun 27, 2022Microbiology

Heparins enhance C1 esterase inhibitor activity: a promising remedy for acute hereditary angioedema

Y. Zhou, A. Maljuf-Cruz, J. Dennis, E. Woroch, L. Hor, B. Hellbusch, E. Archuleta, L. Fornis, C. Garcia, S. Aerts, X. Bai, S. Bevers, E. P. Schmidt, M. Bates, R. Fugit, , E. Chan

This study shows low-molecular weight heparins enhance C1-INH activity in HAE patients and in vitro, suggesting they could be a cost-effective treatment for acute HAE.

bioRxiv · Feb 10, 2022 · PreprintPharmacology & Toxicology

Heparan Sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE

M. Li, C. Y. Ong, C. J. Langouet-Astrie, L. TAN, A. Verma, Y. Yang, X. Zhang, D. Shah, E. P. Schmidt, D. Xu

This study shows that heparan sulfate-dependent RAGE oligomerization is essential for RAGE signaling and demonstrates a monoclonal antibody that blocks this interaction.

eLife · Feb 9, 2022Peer-reviewedCell Biology