Author

C. J. Lingle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:electrophysiology· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

P. L. Martinez-Espinosa· 3 shared X. Xia· 3 shared Y. Zhou· 2 shared A. C. Chen· 1 shared A. Neely· 1 shared C. Yang· 1 shared D. Alvarado· 1 shared G. S. Kallure· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

P. L. Martinez-Espinosa

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5 papers

Recent·Most cited

High-resolution structures illuminate key principles underlying voltage and LRRC26 regulation of Slo1 channels

G. S. Kallure, K. Pal, Y. Zhou, C. J. Lingle, S. Chowdhury

The paper determines high-resolution structures of Slo1 channels with mutations and LRRC26 subunits to elucidate voltage and auxiliary subunit regulation mechanisms.

bioRxiv · Dec 20, 2023 · PreprintBiophysics

Nav1.3 and fibroblast growth factor homologous factor 14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells

P. L. Martinez-Espinosa, C. Yang, X. Xia, C. J. Lingle

This study identifies Nav1.3 and FGF14 as key determinants of TTX-sensitive sodium current properties in mouse adrenal chromaffin cells.

bioRxiv · Oct 31, 2020Biophysics

Fast inactivation of Na+ current in rat adrenal chromaffin cells involves two independent inactivation pathways

P. L. Martinez-Espinosa, A. Neely, J. Ding, C. J. Lingle

The paper investigates two independent inactivation pathways of Na+ current in rat adrenal chromaffin cells and shows how they contribute to use-dependent changes in Nav availability.

bioRxiv · Oct 31, 2020Biophysics

Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice

V. M. Gonzalez-Perez, P. L. Martinez-Espinosa, M. Sala-Rabanal, N. Bharadwaj, X. Xia, A. C. Chen, D. Alvarado, J. K. Gustafsson, H. Hu, M. A. Ciorba, C. J. Lingle

This study shows that LRRC26-associated BK channels in goblet cells protect mice from colitis by regulating potassium flux and MUC2 secretion.

bioRxiv · Oct 23, 2020Physiology

BK channel inhibition by strong extracellular acidification

Y. Zhou, X. Xia, C. J. Lingle

This study shows that extracellular acidification strongly inhibits BK channel activation by shifting its conductance-voltage relationship and blocking voltage-sensor activation through specific acidic residues.

bioRxiv · May 8, 2018Biophysics