Author

M. A. Ciorba

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1

Frequent Co-Authors

S. Ding· 3 shared D. M. Alvarado· 2 shared Q. Zeng· 2 shared A. Antia· 1 shared A. C. Chen· 1 shared A. Koseki· 1 shared A. Kosugi· 1 shared B. T. McCune· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersMicrobiology

S. Ding

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A high-fidelity in vitro model of the human intestinal epithelium

S. Fujii, S. T. Espenschied, V. Anand, J. Bettencourt-Silva, Y. Han, G. Ito, A. Koseki, A. Kosugi, J. Kozlowski, R. Matsumoto, S. Meng, N. Mulligan, R. J. Musich, K. Newhall, E. Ohshina, , T. S. Stappenbeck

This paper develops an in vitro model of the human intestinal epithelium that closely mimics in vivo cell types using single-cell transcriptomics and a biomedical foundation model.

bioRxiv · Jan 1, 2024 · PreprintCell Biology

SARS-CoV-2 Omicron BA.1 variant infection of human colon epithelial cells

A. Antia, D. M. Alvarado, Q. Zeng, D. L. Davis, M. A. Ciorba, S. Ding

This study investigates the infection of human colon epithelial cells by the SARS-CoV-2 Omicron BA.1 variant, finding it infects similarly or less effectively than the ancestral strain and Delta variant.

bioRxiv · Apr 13, 2022Microbiology

Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice.

D. M. Alvarado, J. Son, L. B. Thackray, M. Diamond, S. Ding, M. A. Ciorba, Washington University IBD Investigators Group

This study investigates whether mesalamine affects SARS-CoV-2 infection and disease severity in mice and human intestinal cells, finding no change in viral levels but reduced ACE2 expression.

bioRxiv · Jul 23, 2021Microbiology

Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice

V. M. Gonzalez-Perez, P. L. Martinez-Espinosa, M. Sala-Rabanal, N. Bharadwaj, X. Xia, A. C. Chen, D. Alvarado, J. K. Gustafsson, H. Hu, M. A. Ciorba, C. J. Lingle

This study shows that LRRC26-associated BK channels in goblet cells protect mice from colitis by regulating potassium flux and MUC2 secretion.

bioRxiv · Oct 23, 2020Physiology

TMPRSS2 and TMPRSS4 mediate SARS-CoV-2 infection of human small intestinal enterocytes

R. Zang, M. F. G. Castro, B. T. McCune, Q. Zeng, P. W. Rothlauf, N. M. Sonnek, Z. Liu, K. F. Brulois, X. Wang, H. B. Greenberg, M. S. Diamond, M. A. Ciorba, S. P. J. Whelan, S. Ding

This study shows SARS-CoV-2 infects human intestinal enterocytes via TMPRSS2 and TMPRSS4, but viral particles in stool are inactivated, suggesting limited fecal-oral transmission.

bioRxiv · Apr 21, 2020Microbiology