Author

C. J. Weston

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell-cell communication· 2 Assay:scRNA-seq· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. R. Portman· 2 shared K. P. Matchett· 2 shared N. C. Henderson· 2 shared P. N. Newsome· 2 shared P. Ramachandran· 2 shared R. Dobie· 2 shared S. J. Wigmore· 2 shared A. Geng· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCell Biology

J. R. Portman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Distinct circulating monocytes up-regulate CD52 and sustain innate immune function in patients with cirrhosis unless acute decompensation emerges

A. Geng, R. G. Brenig, J. Roux, M. Luetge, H.-W. Cheng, E. E. Flint, M.-A. Meier, O. T. Pop, P. Kuenzler-Heule, M. McPhail, S. Soysal, D. Semela, M. Heim, C. J. Weston, B. Ludewig, C. Bernsmeier

The paper identifies CD52-expressing monocytes in cirrhosis that enhance innate immunity, but their loss during acute decompensation correlates with infection and poor outcomes.

bioRxiv · Apr 3, 2024 · PreprintImmunology

Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis

P. Horn, J. Norlin, K. Almholt, B. M. Viuff, E. D. Galsgaard, A. Hald, F. Zosel, H. Demuth, S. Poulsen, P. L. Norby, M. G. Rasch, M. Vyberg, M. P. Werge, L. L. Gluud, M. R. Rink, , P. N. Newsome

This study evaluates Gremlin-1 as a therapeutic target in MASH fibrosis, finding it upregulated but not amenable to targeting due to its restricted expression and lack of effect on fibrogenesis.

bioRxiv · Jan 3, 2024Pathology

Multimodal decoding of human liver regeneration

K. P. Matchett, J. W. Wilson-Kanamori, J. R. Portman, A. Kapourani, F. Fercoq, S. May, J. B. Mackey, M. Brice, E. Zajdel, M. Beltran-Sierra, E. F. Sutherland, G. C. Wilson, S. J. Wallace, L. Kitto, N. T. Younger, , N. C. Henderson

This study uses single-nuclei RNA sequencing and spatial profiling to create a single-cell atlas of human liver regeneration, identifying a novel migratory hepatocyte subpopulation and demonstrating that wound closure precedes hepatocyte proliferation.

bioRxiv · Feb 24, 2023Cell Biology

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics

P. Ramachandran, R. Dobie, J. R. Wilson-Kanamori, E. F. Dora, B. E. Henderson, R. S. Taylor, K. P. Matchett, J. R. Portman, M. Efremova, R. Vento-Tormo, N. T. Luu, C. J. Weston, P. N. Newsome, E. M. Harrison, D. J. Mole, , N. C. Henderson

This study uses single-cell transcriptomics to identify novel fibrotic cell types and interactions in human liver cirrhosis, revealing potential therapeutic targets.

Nature · Oct 9, 2019Peer-reviewedImmunology