Author

R. Dobie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Physiology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 7 Assay:scRNA-seq· 6 Approach:experimental assay· 5 Research Focus:cell-cell communication· 4 Organism:mouse· 4 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3

Frequent Co-Authors

N. C. Henderson· 6 shared J. R. Portman· 3 shared C. J. Weston· 2 shared D. A. Gibson· 2 shared D. J. Mole· 2 shared J. R. Wilson-Kanamori· 2 shared K. P. Matchett· 2 shared O. Kelepouri· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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6 shared papersImmunology

N. C. Henderson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response

A. M. Elliot, I. Ribeiro Bravo, J. Astorga Johansson, E. Hutton, R. Cunningham, H. Myllymaki, K. Y. Chang, J. Cholewa-Waclaw, Y. Zhao, R. Dobie, M. Beltran, A. Lewis, P. Elks, C. G. Hansen, N. Henderson, Y. Feng

This study shows that oncogenic Ras in zebrafish skin triggers phenotypic plasticity in specific keratinocytes and promotes tumour-promoting neutrophils within 24 hours.

bioRxiv · Nov 10, 2023 · PreprintCancer Biology

Multimodal decoding of human liver regeneration

K. P. Matchett, J. W. Wilson-Kanamori, J. R. Portman, A. Kapourani, F. Fercoq, S. May, J. B. Mackey, M. Brice, E. Zajdel, M. Beltran-Sierra, E. F. Sutherland, G. C. Wilson, S. J. Wallace, L. Kitto, N. T. Younger, , N. C. Henderson

This study uses single-nuclei RNA sequencing and spatial profiling to create a single-cell atlas of human liver regeneration, identifying a novel migratory hepatocyte subpopulation and demonstrating that wound closure precedes hepatocyte proliferation.

bioRxiv · Feb 24, 2023Cell Biology

Single cell transcriptomics of Atlantic salmon (Salmo salar L.) liver reveals cellular heterogeneity and immunological responses to challenge by Aeromonas salmonicida

R. S. Taylor, R. Ruiz Daniels, R. Dobie, S. Naseer, T. C. Clark, N. C. Henderson, P. Boudinot, S. A. Martin, D. J. Macqueen

This study uses single-cell transcriptomics to analyze liver cellular heterogeneity and immune responses in Atlantic salmon challenged with Aeromonas salmonicida.

bioRxiv · Jul 12, 2022Immunology

Single cell RNA sequencing and lineage tracing confirm mesenchyme to epithelial transformation (MET) contributes to repair of the endometrium at menstruation

P. M. Kirkwood, D. A. Gibson, I. Shaw, R. Dobie, O. Kelepouri, N. C. Henderson, P. T. Saunders

This study identifies a novel population of PDGFRβ+ mesenchymal cells that undergo mesenchyme-to-epithelial transformation during endometrial repair, contributing to tissue regeneration.

bioRxiv · Dec 20, 2021Physiology

Single cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium

P. M. Kirkwood, D. A. Gibson, J. R. Smith, J. R. Wilson-Kanamori, O. Kelepouri, A. Esnal-Zufiaurre, R. Dobie, N. C. Henderson, P. T. Saunders

This study uses single-cell RNA sequencing to redefine the mesenchymal cell landscape in mouse endometrium, identifying five subpopulations including pericytes, vascular smooth muscle cells, and three distinct fibroblast subtypes.

bioRxiv · Aug 20, 2020Physiology

Neutrophils mediate the capture of peritoneal contaminants by fat-associated lymphoid clusters of the omentum

L. H. Jackson-Jones, P. Smith, M. S. Magalhaes, J. R. Portman, K. J. Mylonas, M. Nixon, B. E. P. Henderson, R. Dobie, N. C. Henderson, D. J. Mole, C. Benezech

This study identifies FALC cover cells expressing CXCL1 that recruit neutrophils to neutralize peritoneal contaminants, confirmed in human appendicitis.

bioRxiv · Sep 18, 2019 · PreprintImmunology

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics

P. Ramachandran, R. Dobie, J. R. Wilson-Kanamori, E. F. Dora, B. E. Henderson, R. S. Taylor, K. P. Matchett, J. R. Portman, M. Efremova, R. Vento-Tormo, N. T. Luu, C. J. Weston, P. N. Newsome, E. M. Harrison, D. J. Mole, , N. C. Henderson

This study uses single-cell transcriptomics to identify novel fibrotic cell types and interactions in human liver cirrhosis, revealing potential therapeutic targets.

bioRxiv · Sep 12, 2019Immunology