Author

D. J. Mole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Pathology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

J. P. Iredale· 2 shared J. R. Portman· 2 shared N. C. Henderson· 2 shared R. Dobie· 2 shared S. P. Webster· 2 shared X. Zheng· 2 shared A. Adair· 1 shared A. Christie· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersImmunology

J. P. Iredale

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Author profile →

5 papers

Recent·Most cited

Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis.

B. Higgins, I. Simitsidellis, X. Zheng, F. Collins, N. Homer, S. Denham, J. Simpson, M. Millar, L. Boswell, H. Y. Lee, Y. G. Kim, K. H. Park, L. C. Park, P. J. Sweeney, G. Feraille, , D. J. Mole

This study shows that blocking Kynurenine monooxygenase (KMO) reduces endometriosis-like lesions, alleviates pain, and improves behavior in a mouse model of endometriosis.

bioRxiv · May 13, 2024 · PreprintPathology

Neutrophils mediate the capture of peritoneal contaminants by fat-associated lymphoid clusters of the omentum

L. H. Jackson-Jones, P. Smith, M. S. Magalhaes, J. R. Portman, K. J. Mylonas, M. Nixon, B. E. P. Henderson, R. Dobie, N. C. Henderson, D. J. Mole, C. Benezech

This study identifies FALC cover cells expressing CXCL1 that recruit neutrophils to neutralize peritoneal contaminants, confirmed in human appendicitis.

bioRxiv · Sep 18, 2019 · PreprintImmunology

Resolving the fibrotic niche of human liver cirrhosis using single-cell transcriptomics

P. Ramachandran, R. Dobie, J. R. Wilson-Kanamori, E. F. Dora, B. E. Henderson, R. S. Taylor, K. P. Matchett, J. R. Portman, M. Efremova, R. Vento-Tormo, N. T. Luu, C. J. Weston, P. N. Newsome, E. M. Harrison, D. J. Mole, , N. C. Henderson

This study uses single-cell transcriptomics to identify novel fibrotic cell types and interactions in human liver cirrhosis, revealing potential therapeutic targets.

bioRxiv · Sep 12, 2019Immunology

Patterns of recurrence after curative-intent surgery for pancreas cancer reinforce the importance of locoregional control and adjuvant chemotherapy.

R. Munir, K. Soreide, R. Ravindran, J. J. Powell, E. Harrison, A. Adair, S. Wigmore, R. Parks, O. J. Garden, L. Kirkpatrick, L. R. Wall, A. Christie, I. Penman, N. McAvoy, V. Save, , D. J. Mole

This study examines recurrence patterns in pancreas cancer patients after surgery, finding that locoregional recurrence is common and linked to R+ resection and venous invasion, with adjuvant chemotherapy improving survival.

bioRxiv · Oct 18, 2018 · PreprintPathology

Detecting Drug-Target Binding In Cells Using Fluorescence Activated Cell Sorting Coupled With Mass Spectrometry Analysis

K. Wilson, S. P. Webster, J. P. Iredale, X. Zheng, N. Z. M. Homer, N. Pham, M. Auer, D. J. Mole

This paper introduces a new method called TAPS to assess drug-target binding in cells, demonstrating its effectiveness with the challenging KMO target.

bioRxiv · Apr 3, 2017Pharmacology & Toxicology