R. Mehra

Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer

This study identifies PIKfyve as a targetable vulnerability in pancreatic cancer by showing its role in lipid metabolism and synthetic lethality with KRAS-MAPK inhibitors.

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

Modelling SARS-CoV-2 spike-protein mutation effects on ACE2 binding

This study models SARS-CoV-2 spike-protein mutations' effects on ACE2 binding using computational methods, showing major variants maintain affinity better than random mutations.

Stability and expression of SARS-CoV-2 spike-protein mutations

The paper examines if thermodynamic stability of SARS-CoV-2 S-protein mutants correlates with their expression levels and ACE2 binding, finding significant positive correlations.

Understanding photothermal interactions will help expand production range and increase genetic diversity of lentil (Lens culinaris Medik.)

The paper uses a photothermal model to predict flowering times of lentil genotypes across environments and identifies groups with different temperature and photoperiod sensitivity.

Notch3 promotes prostate cancer-induced bone lesion development via MMP3

This study shows Notch3 promotes osteoblastic bone lesions in prostate cancer by inhibiting osteoclasts and enhancing osteoblasts through MMP-3.