Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells
M. R. Teh, N. Gudgeon, J. N. Frost, L. V. Sinclair, A. L. Smith, C. L. Millington, B. Kronsteiner, J. Roberts, B. P. Marzullo, A. E. Preston, J. Rehwinkel, T. A. Milne, D. A. Tennant, S. J. Dunachie, A. E. Armitage, , H. Drakesmith
This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.
bioRxiv · Feb 1, 2024 · PreprintImmunology