Author

H. Drakesmith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. E. Armitage· 3 shared A. E. Preston· 3 shared J. N. Frost· 3 shared M. R. Teh· 3 shared J. Rehwinkel· 2 shared N. White· 2 shared S. K. Wideman· 2 shared A. Bridgeman· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

A. E. Armitage

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Author profile →

5 papers

Recent·Most cited

Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells

M. R. Teh, N. Gudgeon, J. N. Frost, L. V. Sinclair, A. L. Smith, C. L. Millington, B. Kronsteiner, J. Roberts, B. P. Marzullo, A. E. Preston, J. Rehwinkel, T. A. Milne, D. A. Tennant, S. J. Dunachie, A. E. Armitage, , H. Drakesmith

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

bioRxiv · Feb 1, 2024 · PreprintImmunology

Novel role of bone morphogenetic protein 9 (BMP9) in innate host responses to HCMV infection

M. M. Brinkmann, M. Stempel, H. Drakesmith

This study identifies BMP9 as a novel enhancer of IFNβ antiviral activity against HCMV, which is counteracted by HCMV-encoded proteins US18 and US20.

bioRxiv · Mar 27, 2023Immunology

Cellular iron governs the host response to malaria

S. K. Wideman, J. N. Frost, F. C. Richter, C. Naylor, J. M. Lopes, N. Viveiros, M. R. Teh, A. E. Preston, N. White, S. Yusuf, S. Draper, A. E. Armitage, T. L. Duarte, H. Drakesmith

This study shows that host cell iron scarcity inhibits immune response but reduces liver damage during malaria infection.

bioRxiv · Feb 5, 2023Immunology

Plasma iron controls neutrophil production and function

J. N. Frost, S. K. Wideman, A. E. Preston, M. R. Teh, Z. Ai, L. Wang, A. Cross, N. White, Y. Yazicioglu, M. Bonadonna, A. Clarke, A. E. Armitage, B. Galy, I. A. Udalova, H. Drakesmith

The paper shows hypoferremia reduces neutrophil production and alters their function, while increasing NETosis, and suggests targeting hepcidin could modulate innate immunity.

bioRxiv · Mar 17, 2022Immunology

cGAMP loading enhances the immunogenicity of VLP vaccines

L. Chauveau, A. Bridgeman, T. K. Tan, R. Beveridge, J. Frost, I. Pedroza-Pacheco, T. Partridge, P. Borrow, H. Drakesmith, A. Townsend, J. Rehwinkel

This study shows that incorporating cGAMP into virus-like particles (VLPs) enhances their immunogenicity, leading to stronger T cell responses and antibody titres against HIV and influenza viruses.

bioRxiv · Jan 3, 2020 · PreprintImmunology