Author

C. M. Miton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein sequence· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

N. Tokuriki· 3 shared A. Brown· 1 shared A. Romero-Rivera· 1 shared C. J. Jackson· 1 shared D. F. Ackerley· 1 shared D. Pletzer· 1 shared D. W. Anderson· 1 shared E. C. Campbell· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersEvolutionary Biology

N. Tokuriki

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Author profile →

3 papers

Recent·Most cited

Origin Of Evolutionary Bifurcation In An Enzyme

C. M. Miton, E. C. Campbell, J. A. Kaczmarski, F. Feixas, A. Romero-Rivera, M. Sandhu, D. W. Anderson, N. Shatani, S. Osuna, C. J. Jackson, N. Tokuriki

The paper describes how two distinct enzymes evolved from a common ancestor through different mutational paths, leading to divergent molecular and phenotypic outcomes.

bioRxiv · Nov 25, 2023 · PreprintEvolutionary Biology

Higher-order epistasis creates idiosyncrasy, confounding predictions in protein evolution

K. Buda, C. M. Miton, N. Tokuriki

This study shows that higher-order epistasis causes idiosyncrasy in protein evolution, making predictions unreliable even with epistatic information.

bioRxiv · Sep 7, 2022Evolutionary Biology

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

J. Copp, D. Pletzer, A. Brown, J. van der Heijden, C. M. Miton, R. J. Edgar, M. Rich, R. Little, E. Williams, R. E. W. Hancock, N. Tokuriki, D. F. Ackerley

This paper identifies mechanisms of niclosamide action and resistance in Gram-negative bacteria and demonstrates synergistic combination therapies with efflux inhibitors and membrane permeabilizers.

mBio · Oct 27, 2020Peer-reviewedMicrobiology