Author

D. Pletzer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

R. E. W. Hancock· 3 shared A. Baghela· 1 shared A. Barron· 1 shared A. Brown· 1 shared A. H. Lee· 1 shared A. Wilson· 1 shared B. Lamont· 1 shared B. M. Russell· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersMicrobiology

R. E. W. Hancock

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4 papers

Recent·Most cited

Antiparasitic effect of peptoids against Cryptosporidium parvum

B. Lamont, B. M. Russell, R. Suwanarusk, J. E. Nielsen, K. Sorensen, D. Yung, A. Barron, D. Pletzer, M.-R. Muhsin-Sharafaldine

This study identifies two peptoids, TM9 and TM19, with potent anti-Cryptosporidium parvum activity that does not harm host cells, suggesting their potential as new therapeutics for cryptosporidiosis.

bioRxiv · Jul 16, 2024 · PreprintMicrobiology

The ColR/S two-component system is a conserved determinant of host association across Pseudomonas species

C. L. Wiesmann, Y. Zhang, M. Alford, D. Thoms, M. Dostert, A. Wilson, D. Pletzer, R. E. W. Hancock, C. H. Haney

This study shows the ColR/S two-component system is conserved in Pseudomonas species and required for host association, but its regulon diverges between strains with different lifestyles.

bioRxiv · Dec 14, 2021Microbiology

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

J. Copp, D. Pletzer, A. Brown, J. van der Heijden, C. M. Miton, R. J. Edgar, M. Rich, R. Little, E. Williams, R. E. W. Hancock, N. Tokuriki, D. F. Ackerley

This paper identifies mechanisms of niclosamide action and resistance in Gram-negative bacteria and demonstrates synergistic combination therapies with efflux inhibitors and membrane permeabilizers.

mBio · Oct 27, 2020Peer-reviewedMicrobiology

The stringent stress response controls proteases and global regulators under optimal growth conditions in Pseudomonas aeruginosa

D. Pletzer, T. M. Blimkie, H. Wolfmeier, Y. Li, A. Baghela, A. H. Lee, R. Falsafi, R. E. W. Hancock

This study shows that the stringent stress response, mediated by ppGpp, regulates proteases and global regulators in Pseudomonas aeruginosa under optimal growth conditions, revealing its broad physiological role.

bioRxiv · May 23, 2020Microbiology