Author

R. Little

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

M. Brockhurst· 2 shared R. Jackson· 2 shared S. Bird· 2 shared S. Ford· 2 shared A. Brown· 1 shared A. Piazza· 1 shared C. M. A. Thompson· 1 shared C. M. Miton· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersMicrobiology

M. Brockhurst

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Compensatory mutations reducing the fitness cost of plasmid carriage occur in plant rhizosphere communities

S. Bird, S. Ford, C. M. A. Thompson, R. Little, J. P. J. Hall, R. Jackson, J. G. Malone, E. G. Harrison, M. Brockhurst

The paper shows compensatory mutations reduce the fitness cost of plasmid carriage in Pseudomonas fluorescens in plant rhizosphere communities.

bioRxiv · Aug 1, 2022 · PreprintMicrobiology

Plasmid manipulation of bacterial behaviour through translational regulatory crosstalk

C. Thompson, J. Hall, G. Chandra, C. Martins, G. Saalbach, S. Bird, S. Ford, R. Little, A. Piazza, E. Harrison, R. Jackson, M. Brockhurst, J. Malone

This paper identifies RsmQ as a plasmid translational regulator that globally controls bacterial behavior by altering the proteome, leading to a switch from motile to sessile lifestyle.

bioRxiv · Jun 27, 2022 · PreprintMicrobiology

Potassium effects on NCC are attenuated during inhibition of Cullin E3-ubiquitin ligases

S. K. Murali, R. Little, S. B. Poulsen, M. Ferdaus, D. H. Ellison, J. A. McCormick, R. A. Fenton

This study shows that Cullin E3-ubiquitin ligases, particularly Cul3, modulate potassium's effects on NCC phosphorylation and abundance in the kidney.

bioRxiv · Nov 30, 2021Physiology

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

J. Copp, D. Pletzer, A. Brown, J. van der Heijden, C. M. Miton, R. J. Edgar, M. Rich, R. Little, E. Williams, R. E. W. Hancock, N. Tokuriki, D. F. Ackerley

This paper identifies mechanisms of niclosamide action and resistance in Gram-negative bacteria and demonstrates synergistic combination therapies with efflux inhibitors and membrane permeabilizers.

mBio · Oct 27, 2020Peer-reviewedMicrobiology