Author

R. J. Edgar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. J. Morris· 2 shared J. S. Rush· 2 shared K. V. Korotkov· 2 shared N. Korotkova· 2 shared N. M. van Sorge· 2 shared P. Deng· 2 shared A. Brown· 1 shared A. G. McEwan· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

A. J. Morris

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Author profile →

3 papers

Recent·Most cited

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

J. Copp, D. Pletzer, A. Brown, J. van der Heijden, C. M. Miton, R. J. Edgar, M. Rich, R. Little, E. Williams, R. E. W. Hancock, N. Tokuriki, D. F. Ackerley

This paper identifies mechanisms of niclosamide action and resistance in Gram-negative bacteria and demonstrates synergistic combination therapies with efflux inhibitors and membrane permeabilizers.

mBio · Oct 27, 2020Peer-reviewedMicrobiology

Discovery of glycerol phosphate modification on streptococcal rhamnose polysaccharides

R. J. Edgar, V. P. van Hensbergen, A. Ruda, A. G. Turner, P. Deng, Y. Le Breton, N. M. El-Sayed, A. T. Belew, K. S. McIver, A. G. McEwan, A. J. Morris, G. Lambeau, M. J. Walker, J. S. Rush, K. V. Korotkov, , N. Korotkova

The paper identifies a glycerol phosphate modification on streptococcal rhamnose polysaccharides, revealing its role in host-pathogen interactions and vaccine design.

bioRxiv · Jan 27, 2019Microbiology

The molecular mechanism of N-acetylglucosamine side-chain attachment to the Lancefield group A Carbohydrate in Streptococcus pyogenes

J. S. Rush, R. J. Edgar, P. Deng, J. Chen, H. Zhu, N. M. van Sorge, A. J. Morris, K. V. Korotkov, N. Korotkova

bioRxiv · Oct 6, 2017Microbiology