Author

C. M. O'Mara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

D. A. Bachovchin· 2 shared D. P. Ball· 2 shared E. L. Orth-He· 2 shared H.-C. Huang· 2 shared Q. Wang· 2 shared A. Bhattacharjee· 1 shared A. J. Chui· 1 shared A. R. Griswold· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

D. A. Bachovchin

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2 papers

Recent·Most cited

The NLRP1 and CARD8 inflammasomes detect reductive stress

Q. Wang, J. Hsiao, N. Yardeny, H.-C. Huang, C. M. O'Mara, E. L. Orth-He, D. P. Ball, D. A. Bachovchin

This study identifies chemical probes that induce reductive stress and shows that reductive stress and peptide accumulation together strongly activate NLRP1 and CARD8 inflammasomes.

bioRxiv · Mar 22, 2022Immunology

Cytosolic peptide accumulation activates the NLRP1 and CARD8 inflammasomes

E. L. Orth-He, H.-C. Huang, S. D. Rao, Q. Wang, Q. Chen, C. M. O'Mara, A. J. Chui, M. Saoi, A. R. Griswold, A. Bhattacharjee, D. P. Ball, J. R. Cross, D. A. Bachovchin

This study identifies cytosolic peptide accumulation as a danger signal that activates NLRP1 and CARD8 inflammasomes by promoting NT degradation and disrupting DPP9-mediated sequestration of CT fragments.

bioRxiv · Mar 22, 2022 · PreprintImmunology