Author

J. R. Cross

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. Violante· 2 shared A. Bhattacharjee· 1 shared A. J. Chui· 1 shared A. J. Pickard· 1 shared A. L. Zuckerman· 1 shared A. R. Griswold· 1 shared A. Rao· 1 shared A. Sabovic· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersBiochemistry

S. Violante

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1

S. Khamrui, T. Dodatko, R. Wu, J. Leandro, A. Sabovic, S. Violante, J. R. Cross, E. Marsan, K. Kumar, R. DeVita, M. B. Lazarus, S. Houten

The paper characterizes the human SUGCT enzyme, determines its structure, and identifies inhibitors that may lead to new treatments for glutaric aciduria type 1.

bioRxiv · Feb 7, 2024Biochemistry

A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells

M. L. Heacock, E. N. Abdulaziz, X. Pan, A. L. Zuckerman, S. Violante, C. Yao, J. R. Cross, V. Cracan

This paper introduces a genetically encoded tool to increase the NADH/NAD+ ratio in mammalian cells and characterizes its metabolic and transcriptomic effects.

bioRxiv · Sep 20, 2022 · PreprintBioengineering

Cytosolic peptide accumulation activates the NLRP1 and CARD8 inflammasomes

E. L. Orth-He, H.-C. Huang, S. D. Rao, Q. Wang, Q. Chen, C. M. O'Mara, A. J. Chui, M. Saoi, A. R. Griswold, A. Bhattacharjee, D. P. Ball, J. R. Cross, D. A. Bachovchin

This study identifies cytosolic peptide accumulation as a danger signal that activates NLRP1 and CARD8 inflammasomes by promoting NT degradation and disrupting DPP9-mediated sequestration of CT fragments.

bioRxiv · Mar 22, 2022 · PreprintImmunology

Mapping interactions of microbial metabolites and human receptors

D. A. Colosimo, J. A. Kohn, P. M. Luo, S. M. Han, A. J. Pickard, A. Rao, J. R. Cross, L. J. Cohen, S. F. Brady

The paper identifies bacterial metabolites that activate GPCRs, revealing their role in modulating human health through host-microbe interactions.

bioRxiv · May 3, 2019 · PreprintMicrobiology