Author

T. I. de Silva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Organism:E. coli· 1

Frequent Co-Authors

A. J. Keeley· 2 shared B. B. Lindsey· 2 shared COVID-19 Genomics UK (COG-UK) Consortium· 2 shared M. D. Parker· 2 shared S. L. Rowland-Jones· 2 shared A. Angyal· 1 shared A. Chopra· 1 shared A. J. Mentzer· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMicrobiology

A. J. Keeley

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Efficient overexpression and purification of SARS-CoV-2 Nucleocapsid proteins in Escherichia coli

E. L. Brudenell, M. B. Pohare, D. Zafred, J. Phipps, H. R. Hornsby, J. Darby, J. Dai, E. Liggett, K. Cain, P. E. Barran, T. I. de Silva, J. R. Sayers

The paper describes the scalable production and purification of SARS-CoV-2 nucleocapsid proteins in E. coli and evaluates their use in ELISA assays.

bioRxiv · Jan 8, 2024 · PreprintBiochemistry

The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

T. I. de Silva, G. Liu, B. B. Lindsey, D. Dong, D. Shah, A. J. Mentzer, A. Angyal, R. Brown, M. D. Parker, Z. Yin, X. Yao, L. Turtle, S. Dunachie, COVID-19 Genomics UK (COG-UK) Consortium, M. K. Maini, , T. Dong

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.

iScience · Nov 1, 2021Peer-reviewedImmunology

Comparative genomic analysis of skin and soft tissue Streptococcus pyogenes isolates from low- and high-income settings

S. Y. Bah, A. J. Keeley, E. P. Armitage, H. Khalid, R. R. Chaudhuri, E. Senghore, J. Manneh, L. Tilley, M. Marks, S. Darboe, A. K. Sesay, T. I. de Silva, C. E. Turner, The MRCG StrepA Study Group

This study compares the genomes of Streptococcus pyogenes isolates from low- and high-income settings, revealing genetic diversity and differences in resistance genes and prophage content.

bioRxiv · Sep 10, 2021 · PreprintMicrobiology

The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin

T. P. Peacock, C. M. Sheppard, J. C. Brown, N. Goonawardane, J. Zhou, M. Whiteley, PHE Virology Consortium, T. I. de Silva, W. S. Barclay

This study shows SARS-CoV-2 B.1.617 variants have enhanced spike cleavage by furin due to the P681R mutation, potentially increasing transmissibility and pathogenicity.

bioRxiv · May 28, 2021 · PreprintMicrobiology

Generation of a novel SARS-CoV-2 sub-genomic RNA due to the R203K/G204R variant in nucleocapsid: homologous recombination has potential to change SARS-CoV-2 at both protein and RNA level

S. Leary, S. Gaudieri, M. D. Parker, A. Chopra, I. James, S. Pakala, E. Alves, M. John, B. B. Lindsey, A. J. Keeley, S. L. Rowland-Jones, M. Swanson, D. A. Ostrov, J. L. Bubenik, S. Das, , S. Mallal

The paper identifies a novel SARS-CoV-2 sub-genomic RNA generated by homologous recombination involving the R203K/G204R variant in nucleocapsid, which may enhance viral adaptation and expression.

bioRxiv · Apr 10, 2020 · PreprintMicrobiology