Author

N. Goonawardane

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

J. C. Brown· 2 shared J. Zhou· 2 shared M. Harris· 2 shared PHE Virology Consortium· 2 shared T. P. Peacock· 2 shared W. S. Barclay· 2 shared A. Abdullahi· 1 shared A. Pinto· 1 shared

Activity by Year

2018-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersMicrobiology

J. C. Brown

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Author profile →

6 papers

Recent·Most cited

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

B. Meng, I. Ferreira, A. Abdullahi, N. Goonawardane, A. Saito, I. Kimura, D. Yamasoba, S. A. Kemp, G. Papa, S. Fatihi, S. Rathore, P. Perera Gerba, T. Ikeda, M. Toyoda, T. S. Tan, , S. Zepeda

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

bioRxiv · Dec 17, 2021Microbiology

The SARS-CoV-2 variants associated with infections in India, B.1.617, show enhanced spike cleavage by furin

T. P. Peacock, C. M. Sheppard, J. C. Brown, N. Goonawardane, J. Zhou, M. Whiteley, PHE Virology Consortium, T. I. de Silva, W. S. Barclay

This study shows SARS-CoV-2 B.1.617 variants have enhanced spike cleavage by furin due to the P681R mutation, potentially increasing transmissibility and pathogenicity.

bioRxiv · May 28, 2021 · PreprintMicrobiology

Increased transmission of SARS-CoV-2 lineage B.1.1.7 (VOC 2020212/01) is not accounted for by a replicative advantage in primary airway cells or antibody escape

J. C. Brown, D. H. Goldhill, J. Zhou, T. P. Peacock, R. Frise, N. Goonawardane, L. Baillon, R. Kugathasan, A. Pinto, P. F. McKay, J. Hassard, M. Moshe, A. Singanayagam, T. Burgoyne, the ATACCC Investigators, , W. S. Barclay

This study shows that SARS-CoV-2 variant B.1.1.7 does not replicate better in airway cells or escape antibodies, suggesting its increased transmissibility is due to other factors.

bioRxiv · Feb 24, 2021 · PreprintMicrobiology

Identification of host antiviral genes differentially induced by clinically diverse strains of Tick-Borne Encephalitis Virus

I. M. Jones, N. Goonawardane, U. Laura, M. Harris

This study identifies host antiviral genes differentially induced by high and low pathogenicity TBEV strains in cell culture, highlighting NS5 and host responses as key factors in clinical variability.

bioRxiv · Feb 23, 2021 · PreprintMicrobiology

Association of zinc-finger antiviral protein (ZAP) binding to viral genomic RNA with attenuation of replication of echovirus 7

N. Goonawardane, D. Nguyen, P. Simmonds

This study investigates how ZAP binding to viral RNA affects echovirus 7 replication, showing specific dinucleotide recognition and interactions with OAS3 and stress granules.

bioRxiv · May 14, 2020Microbiology

Multiple roles of the non-structural protein 3 (nsP3) alphavirus unique domain (AUD) during Chikungunya virus genome replication and transcription

Y. Gao, N. Goonawardane, A. Tuplin, M. Harris

This paper identifies multiple roles of the nsP3 AUD domain in CHIKV genome replication and transcription, showing its involvement in RNA replication and virus assembly.

bioRxiv · Jul 25, 2018Microbiology