Author

X.-P. Huang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 5 Organism:mouse· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

B. L. Roth· 4 shared B. K. Shoichet· 2 shared V. Craik· 2 shared A. Alon· 1 shared A. Basbaum· 1 shared A. C. Kruse· 1 shared A. D. White· 1 shared A. I. Basbaum· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersPharmacology & Toxicology

B. L. Roth

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

R. T. Eastman, R. Rusinova, K. F. Herold, X.-P. Huang, P. Dranchak, T. C. Voss, S. Rana, J. H. Shrimp, A. D. White, H. C. Hemmings, B. L. Roth, J. Inglese, O. S. Andersen, J. L. Dahlin

This study shows ivermectin reduces SARS-CoV-2 viral burden in vitro but at concentrations that also cause cytotoxicity, suggesting its antiviral effect may be due to nonspecific membrane perturbation rather than specific antiviral activity.

bioRxiv · Oct 23, 2023 · PreprintPharmacology & Toxicology

Structural Genomics of the Human Dopamine Receptor System

P. Xu, S. Huang, B. E. Krumm, Y. Zhuang, C. Mao, Y. Zhang, Y. Wang, X.-P. Huang, Y.-F. Liu, X. He, H. Li, W. Yin, Y. Jiang, Y. Zhang, B. L. Roth, H. E. Xu

This study reports cryo-EM structures of all human dopamine receptor subtypes bound to Rotigotine, revealing binding modes, activation mechanisms, and G-protein coupling specificity for drug design.

bioRxiv · Oct 9, 2022Biochemistry

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

I. Singh, A. Seth, C. B. Billesbolle, J. Braz, R. M. Rodriguiz, K. Roy, B. Bekele, V. Craik, X.-P. Huang, D. Boytsov, P. Lak, H. R. O'Donnell, W. R. Sandtner, B. L. Roth, A. Basbaum, , G. Rudnick

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

bioRxiv · Jun 13, 2022Biochemistry

Crystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo

A. Alon, J. Lyu, J. M. Braz, T. A. Tummino, V. Craik, M. J. O'Meara, C. M. Webb, D. S. Radchenko, Y. S. Moroz, X.-P. Huang, Y. Liu, B. L. Roth, J. J. Irwin, A. I. Basbaum, B. K. Shoichet, A. C. Kruse

This study uses crystal structures of the σ2 receptor to dock and screen a large library, identifying new chemotypes with high affinity and selectivity for the receptor.

bioRxiv · Apr 29, 2021Pharmacology & Toxicology

A novel G protein-biased and subtype selective agonist for a G protein-coupled receptor discovered from screening herbal extracts

B. Zhang, S. Zhao, D. Yang, Y. Wu, Y. Xin, H. Cao, X.-P. Huang, X. Cai, W. Sun, N. Ye, Y. Xu, Y. Peng, S. Zhao, Z.-J. Liu, G. Zhong, , W. Shui

This study identifies a novel G protein-biased and subtype-selective agonist for the 5-HT2C receptor from herbal extracts, showing efficacy in weight loss similar to lorcaserin.

bioRxiv · Dec 22, 2019Biochemistry