V. Hatzimanikatis

Host metabolic pathways essential for malaria and related hemoparasites in the infection of nucleated cells

The paper identifies host metabolic pathways essential for malaria and related hemoparasites by combining a metabolic model and CRISPR screen.

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

ATLASx: a computational map for the exploration of biochemical space

The paper maps metabolic dark matter by predicting 5 million reactions and integrating 2 million compounds into a global biochemical network called ATLASx.

Database for drug metabolism and comparisons, NICEdrug.ch, aids discovery and design

NICEdrug.ch is a database of 250,000 bio-active molecules that identifies reactive similarities to aid drug discovery, repurposing, and toxicity evaluation.

The architecture of the endoplasmic reticulum is regulated by the reversible lipid modification of the shaping protein CLIMP-63

This paper shows that ZDHHC6-mediated S-palmitoylation of CLIMP-63 regulates ER morphology by controlling its localization and abundance in mammalian cells.

Particle-based simulation reveals macromolecular crowding effects on the Michaelis-Menten mechanism

The paper develops a particle-based simulation framework to quantify how macromolecular crowding affects the Michaelis-Menten kinetics of enzymatic reactions in Escherichia coli.

Identification and dynamics of the DHHC16-DHHC6 palmitoylation cascade

The paper identifies DHHC16 as an upstream palmitoyltransferase regulating DHHC6, revealing a palmitoylation cascade and showing dynamic interconversion of DHHC6 species.