C. Manet

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo, not linked to the type I interferon response.

This study identifies an Irf3 mutation causing defective type-I interferon response in vitro in a susceptible mouse strain but shows other genetic factors are required for in vivo susceptibility to ZIKV.

High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage

This study compares transmissibility and pathogenicity of recent African and Asian Zika virus strains, finding African strains more transmissible, lethal, and capable of causing fetal death.