X. Montagutelli

Multi-target mode of action of Sulfodyne(R), a stabilized Sulforaphane, against pathogenic effects of SARS-CoV-2 infection

This paper shows that Sulfodyne(R), a stabilized Sulforaphane, reduces SARS-CoV-2-induced inflammation and disease severity in cell lines and animal models through mechanisms independent of NRF2 activation.

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo, not linked to the type I interferon response.

This study identifies an Irf3 mutation causing defective type-I interferon response in vitro in a susceptible mouse strain but shows other genetic factors are required for in vivo susceptibility to ZIKV.

SARS-CoV-2 infection in domestic rats after transmission from their infected owner

This study shows SARS-CoV-2 Omicron can infect domestic rats, with one developing severe symptoms, suggesting rodents may contribute to viral spread and evolution.

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

A mRNA vaccine encoding for a RBD 60-mer nanoparticle elicits neutralizing antibodies and protective immunity against the SARS-CoV-2 delta variant in transgenic K18-hACE2 mice

A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice.

This study develops a mouse-adapted SARS-CoV-2 strain that replicates efficiently in standard mice and causes mild to moderate lung disease.

Variants with the N501Y mutation extend SARS-CoV-2 host range to mice, with contact transmission

The paper shows that SARS-CoV-2 variants with the N501Y mutation can infect and transmit to mice, suggesting potential for rodent reservoirs.

A measles-vectored COVID-19 vaccine induces long-term immunity and protection from SARS-CoV-2 challenge in mice

High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage

This study compares transmissibility and pathogenicity of recent African and Asian Zika virus strains, finding African strains more transmissible, lethal, and capable of causing fetal death.

A loss-of-function mutation in Itgal contributes to the high susceptibility of Collaborative Cross strain CC042 to Salmonella infections

This study identifies a loss-of-function mutation in Itgal as a contributor to extreme susceptibility to Salmonella infection in the Collaborative Cross strain CC042.