E. Simon-Loriere

B cell maturation restored ancestral germlines to control Omicron BA.2.86

The paper analyzes neutralizing antibodies from vaccinated and hybrid immune individuals to show that restored B cell germlines enhance neutralization against SARS-CoV-2 variants like BA.2.86.

Neutralisation of SARS-CoV-2 Omicron subvariants BA.2.86 and EG.5.1 by antibodies induced by earlier infection or vaccination

The paper assesses the neutralization of SARS-CoV-2 Omicron subvariants BA.2.86 and EG.5.1 by antibodies from prior infection or vaccination, finding comparable neutralization titres to XBB.1 and EG.5.1.

High fusion and cytopathy of SARS-CoV-2 variant B.1.640.1

This study characterizes the high fusogenicity and cytopathic effects of the SARS-CoV-2 B.1.640.1 variant, identifying mutations in the spike S2 domain responsible for these properties.

Investigations on SARS-CoV-2 and other coronaviruses in mink farms in France at the end of the first year of COVID-19 pandemic

This study investigates SARS-CoV-2 and other viruses in French mink farms, finding high seropositivity and genetic diversity in one farm and co-circulation of other coronaviruses in others.

APOBEC3F is the main source of editing identified during the 2022 outbreak of human monkeypox virus

The paper identifies APOBEC3F as the main source of hypermutation in MPXV during the 2022 outbreak, showing its role in generating G->A mutations and subsequent viral evolution.

Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 Omicron sub-lineages

This study evaluates the neutralizing activity of monoclonal antibodies against SARS-CoV-2 Omicron sub-lineages and finds reduced efficacy against several variants.

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies

This study evaluates the neutralizing antibody resistance of SARS-CoV-2 Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to monoclonal antibodies and sera from vaccinated individuals.

SARS-CoV-2 infection in domestic rats after transmission from their infected owner

This study shows SARS-CoV-2 Omicron can infect domestic rats, with one developing severe symptoms, suggesting rodents may contribute to viral spread and evolution.

Tecovirimat is highly efficient on the Monkeypox virus lineage responsible for the international 2022 outbreak

This study tests tecovirimat's efficacy against the 2022 MPXV outbreak strain, showing nanomolar activity compared to cidofovir's micromolar activity.

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2

This study examines the fusogenicity and neutralization sensitivity of the SARS-CoV-2 AY.4.2 sublineage compared to the Delta variant, finding similar spike function but reduced neutralization sensitivity to certain antibodies and vaccines.

Immune escape of SARS-CoV-2 Omicron variant from mRNA vaccination-elicited RBD-specific memory B cells.

The paper assesses how well mRNA vaccine-induced memory B cells recognize the Omicron variant of SARS-CoV-2 and finds that Omicron evades recognition more than previous variants.

A mouse-adapted SARS-CoV-2 strain replicating in standard laboratory mice.

This study develops a mouse-adapted SARS-CoV-2 strain that replicates efficiently in standard mice and causes mild to moderate lung disease.

Reduced sensitivity of infectious SARS-CoV-2 variant B.1.617.2 to monoclonal antibodies and sera from convalescent and vaccinated individuals

This study shows that the SARS-CoV-2 B.1.617.2 variant is less sensitive to monoclonal antibodies and sera from convalescent and vaccinated individuals compared to other variants.

Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen

The paper identifies DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen, showing it limits viral replication independently of SUMOylation.

Variants with the N501Y mutation extend SARS-CoV-2 host range to mice, with contact transmission

The paper shows that SARS-CoV-2 variants with the N501Y mutation can infect and transmit to mice, suggesting potential for rodent reservoirs.

A measles-vectored COVID-19 vaccine induces long-term immunity and protection from SARS-CoV-2 challenge in mice

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

This study assesses the neutralization sensitivity of SARS-CoV-2 B.1.1.7 and B.1.351 variants compared to D614G using sera and nasal swabs, finding reduced efficacy against B.1.351 in some convalescent and vaccinated individuals.

Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH

This paper introduces CoronaFISH, a method to visualize SARS-CoV-2 RNA in cells and tissues, demonstrating its sensitivity and applicability in various biological contexts.

A novel SARS-CoV-2 related coronavirus in bats from Cambodia

The paper identifies SARS-CoV-2 related coronaviruses in Rhinolophus shameli bats from Cambodia, showing a wider geographic distribution of these viruses than previously known.

High transmissibility and fetal pathogenicity of recent Zika virus strains from the African lineage

This study compares transmissibility and pathogenicity of recent African and Asian Zika virus strains, finding African strains more transmissible, lethal, and capable of causing fetal death.

Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine

This study tests chlorpromazine's antiviral effect on SARS-CoV-2 in human and monkey cells, finding an IC50 of ~10M and suggesting its potential repurposing for COVID-19 treatment.