E. Kornobis

Dynamic microfluidic single-cell screening identifies pheno-tuning compounds to potentiate tuberculosis therapy

The paper develops a microfluidic platform to screen compounds that reduce bacterial phenotypic variation and enhance tuberculosis drug efficacy.

Susceptibility to Zika virus in a Collaborative Cross mouse strain is induced by Irf3 deficiency in vitro but requires other variants in vivo, not linked to the type I interferon response.

This study identifies an Irf3 mutation causing defective type-I interferon response in vitro in a susceptible mouse strain but shows other genetic factors are required for in vivo susceptibility to ZIKV.

Escherichia coli aggregates mediated by native or synthetic adhesins exhibit both core and adhesin-specific transcriptional responses

This study examines transcriptomic responses of E. coli aggregates formed by native or synthetic adhesins, revealing core and adhesin-specific gene expression changes.

Mitochondrial fission process 1 (MTFP1) controls bioenergetic efficiency and prevents inflammatory cardiomyopathy and heart failure in mice

This study shows that MTFP1 is critical for cardiac function, as its loss in mice leads to dilated cardiomyopathy, heart failure, and death due to mitochondrial dysfunction and increased cell death.

Differential transcriptomic response of Anopheles arabiensis to Plasmodium vivax and Plasmodium falciparum infection

This study compares the molecular responses of Anopheles arabiensis to Plasmodium vivax and Plasmodium falciparum infections, identifying differentially expressed genes and long non-coding RNAs.

The Arabidopsis condensin CAP-D subunits arrange interphase chromatin

This study investigates the role of Arabidopsis condensin subunits CAP-D2 and CAP-D3 in interphase chromatin organization, showing their expression patterns and functional impact on chromatin structure and transcription.

A role for differential gene regulation in the rapid diversification of melanic plumage coloration in the dark-eyed junco (Junco hyemalis)

The paper investigates the genetic basis of plumage color differences between two junco subspecies, finding that differential gene regulation, not sequence variation, drives color variation.