Author

C. Mowat

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

K. Baker· 3 shared D. Schiller· 2 shared S. R. Mosley· 2 shared A. Chen· 1 shared A. Namdar· 1 shared D. N. Doell· 1 shared F. Meier-Stephenson· 1 shared S. Choi· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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3 shared papersCancer Biology

K. Baker

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3 papers

Recent·Most cited

Mechanisms of genomic instability dictate cytosolic DNA composition and dendritic cell mediated anti-tumor immunity

S. R. Mosley, A. Chen, D. N. Doell, S. Choi, C. Mowat, F. Meier-Stephenson, V. Meier-Stephenson, K. Baker

The paper shows that genomic instability in MSI CRCs generates cytosolic DNA that enhances STING activation and anti-tumor immunity via dendritic cells, suggesting improved DNA-based therapies for CIN CRCs.

bioRxiv · Mar 8, 2024 · PreprintCancer Biology

cGAS/STING and NLRP3 cooperatively activate CD8+ T cell-mediated anti-tumor immunity in colorectal cancer

C. Mowat, D. Schiller, K. Baker

This study shows that cGAS/STING and NLRP3 pathways work together to enhance CD8+ T cell anti-tumor immunity in colorectal cancer, improving immunotherapy response.

bioRxiv · Aug 22, 2023 · PreprintCancer Biology

Antitumor immunity in dMMR colorectal cancers requires interferon-induced CCL5 and CXCL10

C. Mowat, S. R. Mosley, A. Namdar, D. Schiller, K. Baker

This study identifies that dMMR CRCs recruit CD8+ T cells via CCL5 and CXCL10 overexpression driven by cGAS/STING and IFN signaling, offering a therapeutic target for improving immune response in other CRCs.

bioRxiv · Sep 15, 2020Cancer Biology