C. P. Neu

Intervertebral Disc Elastography to Relate Shear Modulus and Relaxometry in Compression and Bending

This study relates shear modulus and relaxometry in intervertebral discs under compression and bending to assess degeneration.

Multi-frame biomechanical and relaxometry analysis during in vivo loading of the human knee by spiral dualMRI and compressed sensing

This study uses spiral DENSE MRI and compressed sensing to analyze knee cartilage biomechanics during in vivo loading, showing strain patterns and reduced scan times.

A method for defining tissue injury criteria reveals ligament deformation thresholds are multimodal

The paper introduces a method to define tissue injury criteria by analyzing multimodal deformation thresholds in ligaments, revealing hydrostatic strain as a key predictor of collagen denaturation.

Acellular Cartilage-Bone Allografts Restore Structure, Mechanics, and Surface Properties In Vivo, but Limit Recellularization and Integrative Repair

This study shows acellular osteochondral allografts improve cartilage repair in sheep after 6 months but limit recellularization and long-term integration.

Epigenetic Priming Enhances Chondrogenic Potential of Expanded Chondrocytes for Cartilage Repair

This study shows that epigenetic priming of expanded chondrocytes improves their chondrogenic potential when transferred to a 3D environment.

Dedifferentiation alters chondrocyte nuclear mechanics during in vitro culture and expansion

This study shows that dedifferentiated chondrocytes exhibit altered nuclear mechanics and gene expression of nuclear envelope proteins, which may contribute to further dedifferentiation.

Intra-Nuclear Tensile Strain Mediates Reorganization of Epigenetically Marked Chromatin During Cardiac Development and Disease

The paper shows that intra-nuclear tensile strain influences H3K9me3 chromatin reorganization during cardiac development and disease.

Deformation microscopy for dynamic intracellular and intranuclear mapping of mechanics with high spatiotemporal resolution

This paper introduces deformation microscopy to quantify intracellular and intranuclear mechanics with high spatiotemporal resolution, revealing strain dynamics and structural heterogeneity in cells and nuclei.