J. Henderson

Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes

The paper uses proteomics to identify personalized signatures of insulin resistance and type 2 diabetes, showing that fasting proteome and phosphoproteome predict insulin sensitivity and reveal sex-specific differences.

Linear Mixed Model of Virus Disinfection by Chlorine to Harmonize Data Collected Across Broad Environmental Conditions

The paper develops a linear mixed model to estimate chlorine inactivation rate constants for viruses under varying environmental conditions and identifies discrepancies in current disinfection guidelines.

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

The paper shows that CREBBP mutations disrupt chromatin loading dynamics and EP300 redundancy, creating zombie enzymes that impair enhancer activation in GC B-cells and lymphoma.

CD8 T-cell dysfunction is linked with CAR T-cell failure and can be mitigated by a non-alpha IL-2 agonist, pegenzileukin

The paper identifies dysfunctional CD8 CAR T-cells in rrLBCL tumors and shows that pegenzileukin mitigates this dysfunction, improving CAR T-cell responses.

Strong immunogenicity & protection in mice with PlaCCine: A COVID-19 DNA vaccine formulated with a functional polymer

This study evaluates a DNA vaccine, PlaCCine, showing strong immunogenicity and protection in mice against SARS-CoV-2 variants.

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes

This study shows ANXA11 biomolecular condensates couple protein and lipid phase states on lysosomal membranes through interactions with ALG2 and CALC.

Highly contiguous genome assemblies of Photobacterium strains isolatedfrom fish light organs using nanopore sequencing technology

The paper uses nanopore sequencing to assemble high-quality genomes of Photobacterium strains from fish light organs, revealing a new candidate species and gene-host congruency.

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer's R47H mutant does the opposite

The paper shows wild-type sTREM2 inhibits Aβ aggregation and neurotoxicity, while the R47H variant promotes Aβ aggregation and neurotoxicity.

Food web interaction strength distributions are conserved by greater variation between than within predator-prey pairs

The paper examines variation in trophic interaction strengths across and within predator-prey pairs in stream ecosystems, finding that interaction strength distributions remain consistently skewed despite significant variation in feeding rates.

Deformation microscopy for dynamic intracellular and intranuclear mapping of mechanics with high spatiotemporal resolution

This paper introduces deformation microscopy to quantify intracellular and intranuclear mechanics with high spatiotemporal resolution, revealing strain dynamics and structural heterogeneity in cells and nuclei.

What drives interaction strengths in complex food webs? A test with feeding rates of a generalist stream predator

The paper tests factors influencing feeding rates of a stream predator in natural conditions, finding prey density and identity as key predictors.