Author

C. Q. Le

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:cryo-EM· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. A. Wells· 2 shared Y. Zhang· 2 shared A. F. Britol· 1 shared A. Glasgow· 1 shared A. M. Smith· 1 shared A. N. Rizo· 1 shared D. Diwanji· 1 shared E. Hernandez· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

J. A. Wells

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Author profile →

2 papers

Recent·Most cited

A general approach for selection of epitope-directed binders to proteins

j. zhou, C. Q. Le, Y. Zhang, J. A. Wells

This paper introduces a method to select antibodies targeting specific epitopes on proteins by using a decoy antigen and alternating selection rounds, demonstrating its effectiveness with five different antigens.

bioRxiv · Oct 24, 2022Bioengineering

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

S. G. Remesh, G. E. Merz, A. F. Britol, U. S. Chio, A. N. Rizo, T. H. Pospiech, I. Lui, M. T. Laurie, J. Glasgow, C. Q. Le, Y. Zhang, D. Diwanji, E. Hernandez, J. Lopez, K. I. Pawar, , K. A. Verba

The paper develops a computational pipeline combining Rosetta and cryo-EM to analyze ACE2 receptor traps' binding to SARS-CoV-2 variants, showing high affinity and neutralization capabilities against Omicron and Delta.

bioRxiv · Aug 9, 2022Biochemistry