Author

M. T. Laurie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:C. elegans· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

J. DeRisi· 2 shared J. L. DeRisi· 2 shared S. Sunshine· 2 shared A. D. Johnson· 1 shared A. F. Britol· 1 shared A. Glasgow· 1 shared A. J. Hughes· 1 shared A. M. Smith· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

J. DeRisi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Broad sensitivity of Candida auris strains to quinolones and mechanisms of resistance

M. B. Lohse, M. T. Laurie, S. Levan, N. Ziv, C. L. Ennis, C. J. Nobile, J. L. DeRisi, A. D. Johnson

This paper identifies dihalogenated hydroxyquinolines as effective inhibitors of Candida auris with limited resistance development and characterizes the resistance mechanisms.

bioRxiv · Feb 16, 2023 · PreprintMicrobiology

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

S. G. Remesh, G. E. Merz, A. F. Britol, U. S. Chio, A. N. Rizo, T. H. Pospiech, I. Lui, M. T. Laurie, J. Glasgow, C. Q. Le, Y. Zhang, D. Diwanji, E. Hernandez, J. Lopez, K. I. Pawar, , K. A. Verba

The paper develops a computational pipeline combining Rosetta and cryo-EM to analyze ACE2 receptor traps' binding to SARS-CoV-2 variants, showing high affinity and neutralization capabilities against Omicron and Delta.

bioRxiv · Aug 9, 2022Biochemistry

Human sialomucin CD164 is an essential entry factor for lymphocytic choriomeningitis virus

J. Liu, K. A. Knopp, E. Rackaityte, C. Y. Wang, M. T. Laurie, S. Sunshine, A. S. Puschnik, J. DeRisi

This study identifies CD164 as an essential entry factor for LCMV in human cells and tissues, showing its role in viral infection and potential as a therapeutic target.

bioRxiv · Jan 24, 2022 · PreprintMicrobiology

Persistence of ambigrammatic narnaviruses requires translation of the reverse open reading frame

H. Retallack, K. D. Popova, M. T. Laurie, S. Sunshine, J. L. DeRisi

This paper shows that ambigrammatic narnaviruses require translation of a reverse open reading frame for persistence, suggesting a novel viral strategy involving ribosome-mediated protection of viral RNA.

bioRxiv · Dec 18, 2020Microbiology

CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons

R. Tian, M. A. Gachechiladze, C. H. Ludwig, M. T. Laurie, J. Y. Hong, D. Nathaniel, A. V. Prabhu, M. S. Fernandopulle, R. Patel, M. Abshari, M. E. Ward, M. Kampmann

This study develops a CRISPRi platform for genetic screens in human iPSC-derived neurons, identifying gene knockdown effects on survival, transcriptomics, and morphology.

bioRxiv · Jul 3, 2019Cell Biology

Tissue Folding by Mechanical Compaction of the Mesenchyme

A. J. Hughes, H. Miyazaki, M. C. Coyle, J. Zhang, M. T. Laurie, D. Chu, Z. Vavrusova, R. A. Schneider, O. D. Klein, Z. J. Gartner

This study shows mechanical compaction of mesenchyme drives tissue folding in vitro through ECM strain and collagen alignment, without genetic engineering.

bioRxiv · Jul 15, 2017Bioengineering