Author

I. Lui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Bioengineering· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Assay:proteomics· 5 Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:protein folding & dynamics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. A. Wells· 7 shared K. K. Leung· 4 shared S. A. Lim· 4 shared N. J. Rettko· 3 shared P. Solomon· 3 shared X. X. Zhou· 3 shared A. Glasgow· 2 shared B. S. Zha· 2 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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7 shared papersBiochemistry

J. A. Wells

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Multi-scale photocatalytic proximity labeling reveals cell surface neighbors on and between cells

Z. Lin, K. Schaefer, I. Lui, Z. Yao, A. A. Fossati, D. L. Swaney, A. Palar, A. Sali, J. A. Wells

The paper introduces a multi-scale proximity labeling method using Eosin Y to map cell surface protein neighborhoods at varying resolutions and validates interactions of EGFR and CAR-T cell synapses.

bioRxiv · Oct 28, 2023 · PreprintBiochemistry

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

S. G. Remesh, G. E. Merz, A. F. Britol, U. S. Chio, A. N. Rizo, T. H. Pospiech, I. Lui, M. T. Laurie, J. Glasgow, C. Q. Le, Y. Zhang, D. Diwanji, E. Hernandez, J. Lopez, K. I. Pawar, , K. A. Verba

The paper develops a computational pipeline combining Rosetta and cryo-EM to analyze ACE2 receptor traps' binding to SARS-CoV-2 variants, showing high affinity and neutralization capabilities against Omicron and Delta.

bioRxiv · Aug 9, 2022Biochemistry

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2

A. J. Samelson, Q. D. Tran, R. Robinot, L. Carrau, V. V. Rezelj, A. Mac Kain, M. Chen, G. N. Ramadoss, X. Guo, S. A. Lim, I. Lui, J. Nunez, S. J. Rockwood, J. Wang, N. Liu, , M. Kampmann

This study identifies BRD2 as a regulator of ACE2 transcription and shows that BRD2 inhibitors block SARS-CoV-2 infection in human cells and animal models.

bioRxiv · Jan 19, 2021Cell Biology

Bi-paratopic and multivalent human VH domains neutralize SARS-CoV-2 by targeting distinct epitopes within the ACE2 binding interface of Spike

C. J. Bracken, S. A. Lim, P. Solomon, N. J. Rettko, D. P. Nguyen, B. S. Zha, K. Schaefer, J. R. Byrnes, J. Zhou, I. Lui, J. Liu, K. Pance, QCRG Structural Biology Consortium, X. X. Zhou, K. K. Leung, J. A. Wells

This paper identifies and engineers multivalent human VH domains that neutralize SARS-CoV-2 by targeting distinct epitopes on the Spike protein's ACE2 binding interface, showing increased affinity and potency.

bioRxiv · Aug 8, 2020 · PreprintBioengineering

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

A. Glasgow, J. E. Glasgow, D. Limonta, P. Solomon, I. Lui, Y. Zhang, M. A. Nix, N. J. Rettko, S. A. Lim, S. Zha, R. Yamin, K. Kao, O. S. Rosenberg, J. V. Ravetch, A. P. Wiita, , J. A. Wells

This paper describes engineered ACE2 receptor traps that potently neutralize SARS-CoV-2 by blocking viral entry through enhanced binding affinity.

bioRxiv · Jul 31, 2020Bioengineering

Trimeric SARS-CoV-2 Spike interacts with dimeric ACE2 with limited intra-Spike avidity

I. Lui, X. X. Zhou, S. A. Lim, S. Elledge, P. Solomon, N. J. Rettko, B. S. Zha, L. L. Kirkemo, J. A. Gramespacher, J. Liu, F. Muecksch, J. C. C. Lorenzi, F. Schmidt, Y. Weisblum, D. F. Robbiani, , J. A. Wells

This study investigates the interaction between SARS-CoV-2 Spike and ACE2, showing that dimeric ACE2 binds with high affinity to Spike and blocks viral entry, with limited intra-Spike avidity.

bioRxiv · May 21, 2020 · PreprintBiochemistry

Mapping proteolytic neo-N termini at the surface of living cells

A. M. Weeks, J. R. Byrnes, I. Lui, J. A. Wells

The paper develops a method to capture and sequence cell surface N termini in live cells, revealing changes in neo-N termini abundance in response to proteolytic stimuli.

bioRxiv · Feb 23, 2020Biochemistry