Author

A. Glasgow

Cancer Council NSW

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Biophysics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

I. Lui· 2 shared J. A. Wells· 2 shared K. K. Leung· 2 shared O. S. Rosenberg· 2 shared T. Kortemme· 2 shared Y. Zhang· 2 shared A. F. Britol· 1 shared A. Ferrier· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

I. Lui

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance

Ksenija Nesic, John J. Krais, Yifan Wang, Cassandra J. Vandenberg, Pooja Patel, Kathy Qi Cai, Tanya Todorova Kwan, Elizabeth Lieschke, Gwo‐Yaw Ho, Holly E. Barker, Justin Bedő, Silvia Casadei, Andrew Farrell, Marc R. Radke, Kristy Shield‐Artin, , Lyndal S. Edwards

This study identifies secondary splice-site mutations in BRCA1 that drive exon skipping and PARP inhibitor resistance in ovarian and breast cancer.

Molecular Cancer · Aug 5, 2024Peer-reviewedGenetic & Genomic Medicine

An evolutionarily conserved strategy for ribosome binding and inhibition by β-coronavirus non-structural protein 1

S. F. Maurina, J. P. O'Sullivan, G. Sharma, D. C. Pineda Rodriguez, A. MacFadden, F. Cendali, M. A. Henen, J. S. Kieft, A. Glasgow, A.-L. Steckelberg

This paper identifies conserved ribosome-binding mechanisms in β-coronavirus Nsp1 proteins and shows how a cis-acting RNA element modulates Nsp1 function.

bioRxiv · Jun 7, 2023 · PreprintBiochemistry

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

S. G. Remesh, G. E. Merz, A. F. Britol, U. S. Chio, A. N. Rizo, T. H. Pospiech, I. Lui, M. T. Laurie, J. Glasgow, C. Q. Le, Y. Zhang, D. Diwanji, E. Hernandez, J. Lopez, K. I. Pawar, , K. A. Verba

The paper develops a computational pipeline combining Rosetta and cryo-EM to analyze ACE2 receptor traps' binding to SARS-CoV-2 variants, showing high affinity and neutralization capabilities against Omicron and Delta.

bioRxiv · Aug 9, 2022Biochemistry

Ligand-induced changes in dynamics mediate long-range allostery in the lac repressor

A. Glasgow, H. T. Hobbs, Z. R. Perry, S. Marqusee, T. Kortemme

This study uses HDX/MS to show ligand-induced changes in dynamics mediate long-range allostery in the lac repressor, revealing flexibility differences in secondary structures across functional states.

bioRxiv · Nov 30, 2021Biophysics

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

A. Glasgow, J. E. Glasgow, D. Limonta, P. Solomon, I. Lui, Y. Zhang, M. A. Nix, N. J. Rettko, S. A. Lim, S. Zha, R. Yamin, K. Kao, O. S. Rosenberg, J. V. Ravetch, A. P. Wiita, , J. A. Wells

This paper describes engineered ACE2 receptor traps that potently neutralize SARS-CoV-2 by blocking viral entry through enhanced binding affinity.

bioRxiv · Jul 31, 2020Bioengineering