E. A. Newcombe

The importance of stereochemistry in the disorder-order continuum of protein-protein interactions

The paper investigates the role of stereochemistry in disordered protein-protein interactions, finding that chirality is inconsequential in fully disordered complexes but essential when folding and binding are coupled.

Deciphering the alphabet of disorder -- Glu and Asp act differently on local but not global properties

This study compares the functional and structural differences between glutamate and aspartate in intrinsically disordered proteins using experimental and computational methods.

Assessment of models for calculating the hydrodynamic radius of intrinsically disordered proteins

The paper evaluates models for calculating the hydrodynamic radius of intrinsically disordered proteins using conformational ensembles validated by small-angle X-ray scattering and finds the Kirkwood-Riseman equation to be the most accurate.

Monomeric α-Synuclein activates the Plasma Membrane Calcium Pump

This study shows that monomeric α-synuclein activates the plasma membrane calcium pump (PMCA) in neurons, enhancing calcium expulsion through interactions with acidic phospholipids and membrane anchoring.

Refinement of α-synuclein ensembles against SAXS data: Comparison of force fields and methods

The paper compares force fields and methods for refining α-synuclein ensembles using SAXS data, showing that accurate ensembles require compatible simulations and experimental integration.

Tadpole-like conformations of huntingtin exon 1 with expanded polyglutamine engenders novel interactions in cells

The paper investigates the structure of Httex1 with expanded polyQ and finds that its tadpole-like conformation increases interactions in cells, potentially contributing to neurotoxicity.