Author

C. O. Rock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:bacteria (other)· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. Subramanian· 2 shared J. M. Gullett· 2 shared M. W. Frank· 2 shared A. Deik· 1 shared A. T. Nishimoto· 1 shared B. E. Arquilevich· 1 shared B. Jana· 1 shared B. Sundaresh· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

C. Subramanian

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The Bacillus subtilis cell envelope stress-inducible ytpAB operon modulates membrane properties and contributes to bacitracin resistance

J. R. Willdigg, Y. Patel, B. E. Arquilevich, C. Subramanian, M. W. Frank, C. O. Rock, J. D. Helmann

This paper shows that the ytpAB operon, induced by cell wall inhibitors, helps Bacillus subtilis resist bacitracin by modulating membrane properties and interacting with resistance proteins.

bioRxiv · Jan 17, 2024 · PreprintMicrobiology

Vaginal Lactobacillus fatty acid response mechanisms reveal a novel strategy for bacterial vaginosis treatment

M. Zhu, M. W. Frank, C. D. Radka, S. Jeanfavre, M. W. Tse, J. Avila Pacheco, K. Pierce, A. Deik, J. Xhu, S. Hussain, F. A. Hussain, N. Xulu, N. Khan, V. Pillay, K. L. Dong, , D. S. Kwon

This study identifies oleic acid as a compound that inhibits L. iners and promotes L. crispatus growth, offering a potential new treatment strategy for bacterial vaginosis.

bioRxiv · Dec 30, 2023 · PreprintMicrobiology

A genome-wide atlas of antibiotic susceptibility targets and pathways to tolerance.

D. Leshchiner, F. Rosconi, B. Sundaresh, E. Rudmann, L. M. Nieto Ramirez, A. T. Nishimoto, S. Wood, B. Jana, N. Bujan, K. Li, J. Gao, M. Frank, S. M. Reeve, R. E. Lee, C. O. Rock, , T. van Opijnen

This study creates a genome-wide atlas of antibiotic susceptibility targets in Streptococcus pneumoniae, identifying a 'tolerome' that influences resistance and highlights its evolutionary significance.

bioRxiv · Jan 26, 2022Microbiology

Structural transitions permitting ligand entry and exit in bacterial fatty acid binding proteins.

S. W. White, C. O. Rock, E. Tajkhorshid, J. M. Gullett, M. G. Cuypers, C. R. Grace, C. Subramanian, S. Pant

This study reveals how FakB1 transitions between closed and open states to facilitate fatty acid exchange with the membrane.

bioRxiv · Sep 16, 2021 · PreprintBiophysics

Competence-associated peptide BriC alters fatty acid biosynthesis in Streptococcus pneumoniae

S. D. Aggarwal, J. M. Gullett, T. Fedder, J. P. F. Safi, C. O. Rock, N. L. Hiller

This study shows BriC, a communication peptide in Streptococcus pneumoniae, regulates fatty acid biosynthesis by affecting FabT transcription and membrane lipid composition.

bioRxiv · Feb 17, 2021Microbiology