Author

M. E. Tanenbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:imaging· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

J. S. Weissman· 2 shared L. Krenning· 2 shared M. A. Horlbeck· 2 shared M. Jost· 2 shared S. Boersma· 2 shared S. Sonneveld· 2 shared A. Akhmanova· 1 shared A. Barth· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

J. S. Weissman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Zero-mode waveguide nanowells for single-molecule detection in living cells

S. Yang, N. Klughammer, A. Barth, M. E. Tanenbaum, C. Dekker

This paper demonstrates the use of zero-mode waveguide nanowells to enable single-molecule detection in live cells by reducing observation volume and background fluorescence.

bioRxiv · Jun 26, 2023Biophysics

Heterogeneity in viral replication dynamics shapes the antiviral response

L. J. M. Bruurs, M. Müller, J. G. Schipper, H. H. Rabouw, S. Boersma, F. J. M. van Kuppeveld, M. E. Tanenbaum

This study uses live-cell imaging to show that antiviral response activation varies in timing and strength based on viral replication dynamics and signaling pathway strength.

bioRxiv · Jun 8, 2022 · PreprintImmunology

Time-resolved single-cell sequencing identifies multiple waves of mRNA decay during mitotic exit

L. Krenning, S. Sonneveld, M. E. Tanenbaum

The paper identifies two sequential waves of mRNA decay during mitosis-to-G1 transition and links CNOT1 to this process.

bioRxiv · Apr 17, 2021Cell Biology

High-content Imaging-based Pooled CRISPR Screens in Mammalian Cells

X. Yan, N. Stuurman, S. A. Ribeiro, M. E. Tanenbaum, M. A. Horlbeck, C. R. Liem, M. Jost, J. S. Weissman, R. Vale

The paper develops an imaging-based CRISPR screening method called optical enrichment to identify genes affecting nuclear size, identifying 14 hits from 6092 sgRNAs.

bioRxiv · Jun 30, 2020Cell Biology

Pharmaceutical-grade Rigosertib is a Microtubule-destabilizing Agent

M. Jost, Y. Chen, L. A. Gilbert, M. A. Horlbeck, L. Krenning, G. Menchon, A. Rai, M. Y. Cho, J. J. Stern, A. E. Prota, M. Kampmann, A. Akhmanova, M. O. Steinmetz, M. E. Tanenbaum, J. S. Weissman

This paper shows pharmaceutical-grade rigosertib, with high purity, causes microtubule destabilization in cells, confirming its mechanism of action against cancer cells.

bioRxiv · Jan 28, 2020Cancer Biology

Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding

S. Boersma, D. Khuperkar, B. M. P. Verhagen, S. Sonneveld, J. B. Grimm, L. D. Lavis, M. E. Tanenbaum

This study introduces MoonTag, a fluorescence labeling system to visualize single mRNA translation, revealing stochastic start site selection and dynamic regulation in real-time.

bioRxiv · Nov 24, 2018Cell Biology