T. E. McGraw

Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome

This study identifies multiple beta cell-independent mechanisms causing hypoglycemia in Timothy syndrome using a novel mouse model.

GLUT4 dynamic subcellular localization is controlled by AMP kinase activation as revealed by proximal proteome mapping in human muscle cells

The paper uses proximity mapping to show AMPK regulates GLUT4 subcellular localization in muscle cells by controlling exocytosis and endocytosis.

Proximity proteome mapping reveals PD-L1-dependent pathways disrupted by anti-PD-L1 antibody specifically in EGFR-mutant lung cancer cells.

The paper uses proximity proteome mapping to show that anti-PD-L1 therapy disrupts specific PD-L1-dependent pathways in EGFR-mutant lung cancer cells, leading to altered cell migration and EGFR stability.

Blunting of insulin-stimulated glucose uptake in brown adipose tissue induces systemic metabolic dysregulation in female mice

This study shows that reducing glucose uptake in brown adipose tissue in female mice leads to systemic metabolic issues, independent of thermogenesis.

Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant.

This study investigates the impact of a GIPR variant on glucose homeostasis using a mouse model, finding altered intracellular trafficking and increased GIP sensitivity.

Evolution of immune escape mechanisms in the progression from preinvasive to invasive human lung adenocarcinoma.

This study compares the immune microenvironment of preinvasive and invasive lung adenocarcinoma using multiplex immunofluorescence, finding increasing immunosuppression with disease progression.

Insulin promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10.

The paper shows insulin mobilizes GLUT4 from a TGN storage site via RAB10, revealing a non-specific TGN region for cargo transport.