C. S. Sorensen

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

This study identifies H2AX's role in promoting replication fork degradation and chemosensitivity in BRCA-deficient tumours, independent of its classical DNA damage signalling function.

Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low dose treatment of high-grade serous ovarian carcinoma

This study shows that combining low-dose WEE1 and PKMYT1 inhibition synergistically kills ovarian cancer cells by increasing genomic instability and inflammation, and is well-tolerated in mice.

Linker dependence of avidity in multivalent interactions between disordered proteins

This study experimentally examines how linker length affects avidity in bivalent protein interactions and finds that avidity decreases less than predicted by theoretical models.

Effective concentrations enforced by intrinsically disordered linkers are governed by polymer physics

The paper measures effective concentrations of disordered protein linkers and shows they follow polymer physics models, with compaction influenced by charge type and aromatic residues.

Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains

The paper introduces Topokaryotyping, a microscopy-based method to analyze single-cell genomic positioning relative to nuclear landmarks, showing variability and stress-dependent changes in emerin-associated domains.

Mutational signatures reveal the role of RAD52 in p53-independent p21 driven genomic instability

This study shows chronic p21WAF1/Cip1 expression causes genomic instability by suppressing DNA repair pathways, revealing Rad52 as a key player in this process.