Author

V. Gorgoulis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Kotsinas· 2 shared D. Veroutis· 2 shared A. Bergonzini· 1 shared A. G. Tzioufas· 1 shared A. Georgakilas· 1 shared A. Papaspyropoulos· 1 shared A. Polyzos· 1 shared A. Polyzou· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

A. Kotsinas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer

E. Gonzalez-Gualda, D. Macias, S. Morsli, E. Martin, H.-L. Ou, M. Denholm, I. Olan, R. Hoffmann, M. Dane, D. Veroutis, G. Medrano, F. Mulero, C. Martins, M. Barbacid, V. Gorgoulis, , D. Munoz-Espin

This study shows platinum chemotherapy induces a senescent secretome in lung cancer that promotes tumor growth via the TGFβR1/Akt-mTOR axis, and targeting this pathway reduces tumor burden.

bioRxiv · Aug 1, 2022 · PreprintCancer Biology

SARS-CoV-2 infects lung epithelial cells and induces senescence and an inflammatory response in patients with severe COVID-19

K. Evangelou, D. Veroutis, P. G. Foukas, K. Paschalaki, N. Lagopati, M. Dimitriou, A. Papaspyropoulos, O. Hazapis, A. Polyzou, S. Havaki, A. Kotsinas, C. Kittas, A. G. Tzioufas, L. de Leval, D. Vassilakos, , V. Gorgoulis

This study shows SARS-CoV-2 infects alveolar type-2 cells in severe COVID-19 patients, inducing senescence and proinflammatory cytokine expression.

bioRxiv · Jan 2, 2021 · PreprintCell Biology

Influence of the microenvironment on the modulation of the host response by the typhoid toxin

O. C. Martin, D. Butter, E. Paparouna, S. D. Theodorou, M. M. Haykal, E. Boutet-Robinet, T. Tebaldi, A. Bergonzini, M. Lopez Chiloeches, A. Wakeham, M. Rhen, T. Mak, V. Gorgoulis, I. S. Pateras, T. Frisan

This study investigates how typhoid toxin modulates host immune responses in health and disease by inducing DNA damage and senescence, with effects dependent on the host's inflammatory state.

bioRxiv · Jun 4, 2020Immunology

Mutational signatures reveal the role of RAD52 in p53-independent p21 driven genomic instability

P. Galanos, G. Pappas, A. Polyzos, A. Kotsinas, I. Svolaki, N. Giakoumakis, C. Glytsou, I. Pateras, U. Swain, V. Souliotis, A. Georgakilas, N. Geacintov, L. Scorrano, C. Lukas, J. Lukas, , V. Gorgoulis

This study shows chronic p21WAF1/Cip1 expression causes genomic instability by suppressing DNA repair pathways, revealing Rad52 as a key player in this process.

bioRxiv · Sep 28, 2017Cancer Biology