Author

A. N. Kousholt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

J. Jonkers· 2 shared A. A. Sartori· 1 shared A. Duarte· 1 shared C. S. Sorensen· 1 shared D. Dibitetto· 1 shared E. Gogola· 1 shared E. Rothenberg· 1 shared F. Vivalda· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

J. Jonkers

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2 papers

Recent·Most cited

H2AX promotes replication fork degradation and chemosensitivity in BRCA-deficient tumours

D. Dibitetto, M. Liptay, F. Vivalda, E. Gogola, H. Dogan, M. G. Fernandez, A. Duarte, J. A. Schmid, S. T. Durant, J. V. Forment, I. Klebic, M. Siffert, R. de Brujin, A. N. Kousholt, N. A. Marti, , S. Rottenberg

This study identifies H2AX's role in promoting replication fork degradation and chemosensitivity in BRCA-deficient tumours, independent of its classical DNA damage signalling function.

bioRxiv · May 22, 2023Cancer Biology

PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps

K. Cong, A. N. Kousholt, M. Peng, N. J. Panzarino, W. T. C. Lee, S. Nayak, J. Krais, J. Calvo, M. Bere, E. Rothenberg, N. Johnson, J. Jonkers, S. Cantor

This study shows PARPi sensitivity in BRCA-deficient cells arises from replication-associated ssDNA gaps, not replication speed.

bioRxiv · Sep 25, 2019Cancer Biology