Author

T. Souza

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. Ferreira· 2 shared C. de Freitas· 2 shared C. Sacramento· 2 shared F. Bozza· 2 shared G. Barbosa-Lima· 2 shared M. Bastos· 2 shared M. Mattos· 2 shared N. Boechat· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

A. Ferreira

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Omega-3 polyunsaturated fatty acids modify glucose metabolism in THP-1 monocytes

M. J. Byun, R. Armon, T. Souza, H. D. Anderson, A. Saleem, S. D. Pauls

This study shows that ALA and DHA reduce oxidative phosphorylation and increase glycolysis in THP-1 monocytes, possibly via upregulation of PDK4.

bioRxiv · Mar 1, 2024Cell Biology

Unveiling the antiviral capabilities of targeting Human Dihydroorotate Dehydrogenase against SARS-CoV-2

A. Purificacao, S. Silva-Mendonca, L. Cruz, C. Sacramento, J. Temerozo, N. Fintelman-Rodrigues, C. Freitas, B. Godoi, M. Vaidergorn, J. Leite, L. Alvarez, M. Freitas, M. Silva, B. Martin, R. Lopez, , C. Nonato

This study identifies quinone-based compounds that inhibit HsDHODH and show anti-SARS-CoV-2 activity with low toxicity and nanomolar IC50.

bioRxiv · Oct 4, 2023Biochemistry

Analysis of the small chromosomal Prionium serratum (Cyperid) demonstrates the importance of a reliable method to differentiate between mono- and holocentricity

M. Baez, Y.T. Kuo, Y. Dias, T. Souza, A. Boudichevskaia, J. Fuchs, V. Schubert, A.L.L. Vanzela, A. Pedrosa-Harand, A. Houben

The study analyzes Prionium serratum chromosomes to determine centromere organization, finding monocentricity instead of holocentricity and suggesting holocentricity evolved independently in two lineages.

bioRxiv · Jul 8, 2020Evolutionary Biology

Beyond members of the Flaviviridae family, sofosbuvir also inhibits chikungunya virus replication

A. Ferreira, P. Reis, C. de Freitas, C. Queiroz, L. Villas Boas Hoelz, M. Bastos, M. Mattos, E. Correia Loiola, P. Trindade, Y. Rangel Vieira, G. Barbosa-Lima, H. de Castro Faria Neto, N. Boechat, S. Rehen, K. Bruning, , T. Souza

This study shows sofosbuvir inhibits chikungunya virus replication in cell cultures and animal models, with selectivity over ribavirin and efficacy in vivo.

bioRxiv · Jul 2, 2018Microbiology

Yellow fever virus is susceptible to sofosbuvir both in vitro and in vivo

C. de Freitas, L. Higa, C. Sacramento, A. Ferreira, P. Reis, R. Delvecchio, F. Monteiro, G. Barbosa-Lima, Y. Vieira, M. Mattos, L. Hoelz, R. Leme, M. Bastos, F. Bozza, P. Bozza, , T. Souza

This study shows that sofosbuvir inhibits Yellow fever virus replication in vitro and protects mice from infection, suggesting it as a potential therapeutic option.

bioRxiv · Feb 15, 2018Microbiology