Author

R. Debernardo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

O. Reizes· 4 shared C. M. Michener· 2 shared C. Saygin· 2 shared E. Esakov· 2 shared J. Lathia· 2 shared P. G. Rose· 2 shared A. B. Nagaraj· 1 shared A. Chumakova· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersCancer Biology

O. Reizes

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Author profile →

4 papers

Recent·Most cited

Leveraging the p53 signaling pathway as a radio-sensitization strategy in endometrial cancer

R. Vargas, A. Petty, A. Durmaz, K. Lin-Rahardja, O. Reizes, R. Debernardo, J. Scott

This study investigates how p53 signaling alterations affect radiotherapy response in endometrial cancer and explores p53 as a radio-sensitization strategy.

bioRxiv · Sep 6, 2022 · PreprintCancer Biology

Single-Cell Analysis of Hyperthermic Intraperitoneal Chemotherapy Treated Tumors Reveals Distinct Cellular and Molecular Responses

M. P. Horowitz, Z. Alali, T. Alban, C. Hong, E. Esakov, T. H. Hwang, J. Lathia, C. M. Michener, R. DeBernardo, O. Reizes

This study uses single-cell RNA-seq to analyze tumor responses to HIPEC in ovarian cancer patients, identifying distinct cellular and molecular changes.

bioRxiv · Oct 5, 2020 · PreprintCancer Biology

Pretreatment with LCK Inhibitors Chemosensitizes Cisplatin-Resistant Endometrioid Ovarian Tumors

K. K. Crean-Tate, C. Braley, G. Dey, E. Esakov, C. Saygin, A. Trestan, D. J. Silver, S. M. Turaga, E. V. Connor, R. Debernardo, C. M. Michener, P. G. Rose, J. Lathia, O. Reizes

This study shows that pretreatment with LCK inhibitors makes cisplatin-resistant endometrioid ovarian tumors more sensitive to cisplatin, improving cell viability and tumor growth inhibition.

bioRxiv · Jun 18, 2020Cancer Biology

CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors

C. Saygin, A. Wiechert, V. S. Rao, R. Alluru, E. Connor, P. S. Thiagarajan, J. S. Hale, Y. Li, A. Chumakova, A. Jarrar, Y. Parker, D. J. Lindner, A. B. Nagaraj, J. J. Kim, A. DiFeo, , O. Reizes

This study identifies CD55 as a signaling hub that regulates self-renewal and cisplatin resistance in endometrioid tumors through distinct signaling pathways.

bioRxiv · Jun 27, 2017Cancer Biology