Author

C. T. Brown

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:metagenomics· 5 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:clustering· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:ecology & biodiversity· 2 Organism:human· 2

Frequent Co-Authors

B. Firek· 2 shared J. F. Banfield· 2 shared M. R. Olm· 2 shared R. Baker· 2 shared A. D. Jungblut· 1 shared A. Das· 1 shared B. C. Thomas· 1 shared B. Montpetit· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

B. Firek

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

DNA targeting by compact Cas9d and its resurrected ancestor

R. Fregoso Ocampo, J. P. Bravo, T. L. Dangerfield, I. Noceda, S. Jirde, L. M. Alexander, A. Das, S. Nielsen, K. A. Johnson, C. T. Brown, C. N. Butterfield, D. S. Goltsman, D. W. Taylor

This study reports cryo-EM structures of Cas9d, revealing its DNA targeting mechanism and demonstrating a compact variant with robust nuclease activity in mammalian cells.

bioRxiv · Apr 8, 2024 · PreprintBiochemistry

Biogeographic Distribution of Five Antarctic Cyanobacteria Using Large-Scale k-mer Searching with sourmash branchwater

J. Lumian, D. Sumner, C. Grettenberger, A. D. Jungblut, L. Irber, N. T. Pierce-Ward, C. T. Brown

This study uses k-mer searching to identify the global distribution of five Antarctic cyanobacteria MAGs across 498,942 metagenomes, revealing distinct biogeographic patterns.

bioRxiv · Oct 27, 2022Microbiology

Candidatus Nealsonbacteria (OD1) are biomass recycling ectosymbionts of methanogenic archaea in a stable benzene-degrading enrichment culture

X. Chen, O. Molenda, C. T. Brown, C. R. A. Toth, S. Guo, F. Luo, J. Howe, C. L. Nesbo, C. He, E. A. Montabana, J. H. D. Cate, J. F. Banfield, E. A. Edwards

The paper identifies Ca. Nealsonbacteria DGGOD1a as a biomass recycling ectosymbiont of methanogenic archaea in a benzene-degrading consortium.

bioRxiv · Apr 20, 2022 · PreprintMicrobiology

Mapping global shifts in Saccharomyces cerevisiae gene expression across asynchronous time trajectories with diffusion maps

T. Reiter, R. Montpetit, R. Runnebaum, C. T. Brown, B. Montpetit

The paper develops a method to analyze asynchronous gene expression time series in yeast fermentations, identifying vineyard-specific gene expression deviations linked to fermentation outcomes.

bioRxiv · Feb 11, 2021Microbiology

Comparing faster evolving rplB and rpsC versus SSU rRNA for improved microbial community resolution

J. Guo, J. R. Cole, C. T. Brown, J. M. Tiedje

The paper compares the resolution of rplB and rpsC with SSU rRNA in microbial communities, finding that the protein-coding genes provide better separation and diversity estimates.

bioRxiv · May 13, 2019 · PreprintMicrobiology

Shifts in microbial transcription patterns prior to onset of Necrotizing enterocolitis may indicate low oxygen levels in the gut

Y. Sher, M. R. Olm, T. Raveh-Sadka, C. T. Brown, R. Sher, B. Firek, R. Baker, M. Morowitz, J. Banfield

The paper identifies shifts in microbial transcription patterns in preterm infants prior to NEC onset, suggesting hypoxic conditions in the gut.

bioRxiv · Nov 9, 2018 · PreprintMicrobiology

Hospitalized premature infants are colonized by related bacterial strains with distinct proteomic profiles

C. T. Brown, W. Xiong, M. R. Olm, B. C. Thomas, R. Baker, B. Firek, M. J. Morowitz, R. L. Hettich, J. F. Banfield

This study examines microbial colonization in premature infants, finding distinct proteomic profiles among related bacterial strains and correlations with NEC development.

bioRxiv · Mar 6, 2018Microbiology