The adenosine 2a receptor and TIM3 directly inhibit killing of tumor cells by cytotoxic T lymphocytes through interference with cytoskeletal polarization
G. L. Edmunds, C. W. L. Wong, R. Ambler, E. Milodowski, H. Alamir, S. J. Cross, G. Galea, C. Wuelfing, D. J. Morgan
This study identifies adenosine 2a receptor and TIM3 as inhibitors of CTL-mediated tumor cell killing by interfering with cytoskeletal polarization and infiltration.
bioRxiv · May 20, 2021Immunology