Author

S. J. Cross

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Wuelfing· 2 shared A. M. Phillips· 1 shared A. M. Toye· 1 shared A. Veler· 1 shared A. W. Dowsey· 1 shared B. Simonetti· 1 shared C. E. Severn· 1 shared C. W. L. Wong· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

C. Wuelfing

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Author profile →

3 papers

Recent·Most cited

Five inhibitory receptors display distinct vesicular distributions in T cells

J. Lu, A. Veler, B. Simonetti, T. Raj, P. H. Chou, S. J. Cross, A. M. Phillips, X. Ruan, L. Huynh, A. W. Dowsey, D. Ye, R. F. Murphy, P. Verkade, P. J. Cullen, C. Wuelfing

The paper characterizes the subcellular distributions of five inhibitory receptors in T cells and finds they are distinct, with CTLA-4 preferentially associating with lysosomal-derived vesicles.

bioRxiv · Jul 21, 2023Immunology

Characterizing the polarization continuum of macrophage subtypes M1, M2a and M2c

T. C. Oates, P. L. Moura, S. J. Cross, K. Roberts, H. E. Baum, K. Haydn-Smith, M. C. Wilson, K. J. Heesom, C. E. Severn, A. M. Toye

This study characterizes four macrophage subtypes using proteomics and functional assays, showing M2c macrophages upregulate pro-inflammatory markers and dexamethasone induces partial repolarization from M1 to M2c.

bioRxiv · Jun 13, 2022Immunology

The adenosine 2a receptor and TIM3 directly inhibit killing of tumor cells by cytotoxic T lymphocytes through interference with cytoskeletal polarization

G. L. Edmunds, C. W. L. Wong, R. Ambler, E. Milodowski, H. Alamir, S. J. Cross, G. Galea, C. Wuelfing, D. J. Morgan

This study identifies adenosine 2a receptor and TIM3 as inhibitors of CTL-mediated tumor cell killing by interfering with cytoskeletal polarization and infiltration.

bioRxiv · May 20, 2021Immunology