Author

C. M. Jeffries

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2 Microbiology· 2 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 3 Research Focus:protein structure prediction· 3 Assay:protein structure· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Approach:benchmark study· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

D. I. Svergun· 4 shared J. E. Deane· 3 shared S. C. Graham· 3 shared C. M. Crump· 2 shared E. R. Caroe· 2 shared M. Shamin· 2 shared T. H. Benedyk· 2 shared V. Connor· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersBiochemistry

D. I. Svergun

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Author profile →

8 papers

Recent·Most cited

Structural characterization of the Pseudomonas Aeruginosa MexR-mexR repressor-operator complex: a small-angle X-ray and neutron scattering perspective

Z. Pietras, F. Caporaletti, C. M. Jeffries, V. Morad, B. Wallner, A. Martel, M. Sunnerhagen

This study characterizes the structure of the MexR-mexR repressor-operator complex using SAXS and SANS, revealing DNA bending and flexibility between binding sites.

bioRxiv · Apr 2, 2024 · PreprintBiophysics

Structure of the N-terminal didomain d1_d2 of the Thrombospondin type-1 domain-containing 7A

A. Bochel, S. A. Mortensen, L. Seifert, F. E. Hengel, C. M. Jeffries, G. Chojnowski, O. Kretz, T. B. Huber, N. M. Tomas, M. Wilmanns

This study determines the structure of the N-terminal didomain d1_d2 of THSD7A, revealing a non-canonical thrombospondin repeat fold with unique structural features contributing to its antigenicity.

bioRxiv · May 3, 2023 · PreprintBiophysics

Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity

B. Goretzki, C. Wiedemann, B. A. McCray, S. L. Schaefer, J. Jansen, F. Tebbe, S.-A. Mitrovic, J. Noeth, J. Donohue, C. M. Jeffries, W. Steinchen, F. Stengel, C. J. Sumner, G. Hummer, U. A. Hellmich

The paper investigates how disordered regions in TRPV4 modulate channel activity through lipid-dependent interactions and identifies a conserved autoinhibitory patch that regulates PIP2 binding.

bioRxiv · Dec 21, 2022Biophysics

MIADE metadata guidelines: Minimum Information About a Disorder Experiment

B. Meszaros, A. Hatos, N. Palopoli, F. Quaglia, E. Salladini, K. Van Roey, H. Arthanari, Z. Dosztanyi, I. C. Felli, P. D. Fischer, J. Hoch, C. M. Jeffries, S. Longhi, E. Maiani, S. Orchard, , N. E. Davey

The paper introduces MIADE guidelines to standardize metadata for experiments studying intrinsically disordered proteins, improving data interpretation and reproducibility.

bioRxiv · Jul 12, 2022 · PreprintScientific Communication & Education

Determinants of receptor tyrosine phosphatase homophilic adhesion: structural comparison of PTPRK and PTPRM extracellular domains

I. M. Hay, M. Shamin, E. R. Caroe, A. S. A. Mohammed, D. I. Svergun, C. M. Jeffries, S. C. Graham, H. J. Sharpe, J. E. Deane

This study compares the structural features of PTPRK and PTPRM extracellular domains to identify determinants of homophilic adhesion, finding that shape complementarity and limited sequence differences drive specificity.

bioRxiv · Jun 23, 2022Biochemistry

Herpes simplex virus 1 protein pUL21 stimulates cellular ceramide transport by activating CERT

T. H. Benedyk, V. Connor, E. R. Caroe, M. Shamin, D. I. Svergun, J. E. Deane, C. M. Jeffries, C. M. Crump, S. C. Graham

This paper shows HSV-1 protein pUL21 activates CERT to increase ceramide to sphingomyelin conversion, but does not affect virus replication or spread.

bioRxiv · Jun 1, 2022Microbiology

pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread

T. H. Benedyk, J. Muenzner, V. Connor, Y. Han, K. Brown, K. J. Wijesinghe, Y. Zhuang, S. Colaco, G. A. Stoll, O. S. Tutt, S. Svobodova, D. I. Svergun, N. A. Bryant, J. E. Deane, A. E. Firth, , S. C. Graham

This study identifies pUL21 as a viral phosphatase adaptor that promotes HSV-1 replication and spread by directing dephosphorylation and antagonizing pUS3 kinase activity.

bioRxiv · Apr 13, 2021Microbiology

Functional interaction of low-homology FRPs from different cyanobacteria with Synechocystis OCP

Y. B. Slonimskiy, E. G. Maksimov, E. P. Lukashev, M. Moldenhauer, C. M. Jeffries, D. I. Svergun, T. Friedrich, N. N. Sluchanko

The paper investigates the functional interaction of low-homology FRPs from different cyanobacteria with Synechocystis OCP, revealing distinct binding properties despite similar structural conformations.

bioRxiv · Jan 15, 2018Biochemistry