M. P. Snyder

Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease

This study tracks microbiome changes across four body sites in 86 participants over six years, revealing site-specific stability, individualized dynamics, and altered patterns in insulin-resistant individuals.

Accelerated Hematopoietic Stem Cell Aging in Space

This study shows spaceflight accelerates hematopoietic stem cell aging through molecular changes like reduced dormancy and mutagenesis, suggesting potential for prevention.

Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue level

This study maps ovarian cancer spatial organization and identifies immune evasion drivers through single-cell spatial transcriptomics and CRISPR screens.

Gut microbiota analyses of Saudi populations for type 2 diabetes-related phenotypes reveals significant association

The paper analyzes gut microbiota in Saudi populations to identify associations with type 2 diabetes, finding increased Firmicutes abundance and a higher Firmicutes/Bacteroidetes ratio in diabetics.

Endogenous Retroviral Elements Generate Pathologic Neutrophils and Elastase Rich Exosomes in Pulmonary Arterial Hypertension

The paper shows that endogenous retroviruses contribute to neutrophil dysfunction and exosome-mediated pulmonary arterial hypertension.

Convergent mutations in tissue-specific regulatory regions reveal novel cancer drivers

This study identifies non-coding cancer drivers by analyzing convergent mutations in tissue-specific regulatory regions across multiple cancer types, finding several genes associated with survival.

Longitudinal linked read sequencing reveals ecological and evolutionary responses of a human gut microbiome during antibiotic treatment

This study uses linked-read sequencing to track genetic and ecological changes in a human gut microbiome during antibiotic treatment and recovery.